Publication

Sensing with Dynamic Combinatorial Libraries of Metal-Dye Complexes: The Advantage of Time-Resolved Measurements

Publications associées (22)

Genetic Algorithms for the Discovery of Homogeneous Catalysts

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In this account, we discuss the use of genetic algorithms in the inverse design process of homogeneous catalysts for chemical transformations. We describe the main components of evolutionary experiments, specifically the nature of the fitness function to o ...

2023

Technology Mapping Using Multi-output Library Cells

Giovanni De Micheli, Alessandro Tempia Calvino

Technology mapping transforms a technology-independent representation into a technology-dependent one given a library of cells. Even if technology libraries contain multi-output cells, state-of-the-art techniques fully exploit single-output cells only. Mul ...

2023

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

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Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an original approa ...

Nature Portfolio2023

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Gontran Sangouard

Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...

EPFL2022

De novo developed small cyclic peptides that are orally available

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Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...

EPFL2022

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Efficient use of energy is essential for today's supercomputing systems, as energy cost is generally a major component of their operational cost. Research into "green computing" is needed to reduce the environmental impact of running these systems. As such ...

IEEE COMPUTER SOC2022

Methods for the generation of large combinatorial macrocycle libraries

Sevan Mleh Habeshian

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

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Tamaas: a library for elastic-plastic contact of periodic rough surfaces", published in the Journal of Open Source Softwares describes the free and open-source library Tamaas. More than five years in the making, Tamaas is a high performance C++/Python libr ...

2020

Cyclometalated Ir(III) complexes as tuneable multiband light sources for optical multisensor systems: Feasibility study

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Development of novel analytical devices complying with modern requirements of simplicity and cost-effectiveness is an important task. Multisensor systems based on various types of chemical sensors are promising tools in this respect. Herein the development ...

2020

UV-Irradiated 2-Keto-(1-C-13)Isocaproic Acid for High-Performance C-13 Hyperpolarized MR

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Enhancing the sensitivity of magnetic resonance spectroscopy/imaging (MRS/MRI) by dissolution dynamic nuclear polarization (dDNP) has expanded the scope of MRS applications to new fields of research. Most importantly, it has paved the way toward noninvasiv ...

AMER CHEMICAL SOC2020

The LifeV library: engineering mathematics beyond the proof of concept

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2018

Multi-Library Coded Caching

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We study the problem of coded caching when the server has access to several libraries and each user makes independent requests from every library. The single-library scenario has been well studied and it has been proved that coded caching can significantly ...

2016

Effects of a neuromuscular controller on a powered ankle exoskeleton during human walking

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Wearable devices to assist abnormal gaits require controllers that interact with the user in an intuitive and unobtrusive manner. To design such a controller, we investigated a bio-inspired walking controller for orthoses and prostheses. We present (i) a S ...

Ieee2016

Novel Approaches in Cold Ion Spectroscopy for Structural Characterization of Biomolecules in the Gas Phase

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Encoded libraries of chemically modified peptides

Christian Heinis

The use of powerful technologies for generating and screening DNA-encoded protein libraries has helped drive the development of proteins as pharmaceutical ligands. However the development of peptides as pharmaceutical ligands has been more limited. Althoug ...

Elsevier2015

A Pyridine-Based Ligand with Two Hydrazine Functions for Lanthanide Chelation: Remarkable Kinetic Inertness for a Linear, Bishydrated Complex

Lothar Helm, Eva Jakab Toth

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American Chemical Society2015

Measured binding coefficients for iodine and ruthenium dyes; implications for recombination in dye sensitised solar cells

Shaik Mohammed Zakeeruddin, Robin Humphry-Baker, Xiong Li, Filippo de Angelis

We have measured the binding coefficients of iodine to three dyes used in Dye Sensitised Solar Cells (DSSCs). Binding coefficients are quantified via the effect of iodine binding on the UV-vis spectrum of the dye. From iodine titration curves of dye sensit ...

Royal Society of Chemistry2012

UV and IR spectroscopy of cold 1,2-dimethoxybenzene complexes with alkali metal ions

Oleg Boyarkine, Thomas Rizzo, Yoshiya Inokuchi

We report UV photodissociation (UVPD) and IR-UV double-resonance spectra of 1,2-dimethoxybenzene (DMB) complexes with alkali metal ions, M+•DMB (M = Li, Na, K, Rb, and Cs), in a cold 22-pole ion trap. The UVPD spectrum of the Li+ complex shows a strong ori ...

2012

Ultrafast One- and Two-Dimensional UV Transient Absorption Spectroscopy of Haem Proteins

Cristina Consani

Proteins are dynamic macromolecules, which accomplish biological function driven by long-range interactions and global motions. While their biological function is often clear, little is known about the collective interactions which make these systems real ...

EPFL2012