The Mind Behind the Hebbian Synapse Donald O Hebb

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Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Mapping behavioural actions to neural activity is a fundamental goal of neuroscience. As our ability to record large neural and behavioural data increases, there is growing interest in modelling neural dynamics during adaptive behaviours to probe neural re ...

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

Over the course of a lifetime, the human brain acquires an astonishing amount of semantic knowledge and autobiographical memories, often with an imprinting strong enough to allow detailed information to be recalled many years after the initial learning exp ...

Calling for increased action on climate change, Fridays for Future (FFF) quickly gained momentum around the world and became highly visible through strikes and protests in more than 150 countries. Considering its scale and magnitude, questions about the im ...

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...

Understanding how neural circuits remodel and adapt to animal behavior is a central theme in the field of Neuroscience. One strategy to reach this goal is to repeatedly record the same animal's neural circuits and observe how they adapt when facing differe ...

Bottom-up models of functionally relevant patterns of neural activity provide an explicit link between neuronal dynamics and computation. A prime example of functional activity patterns are propagating bursts of place-cell activities called hippocampal rep ...

Objective: Depotentiation of homosynaptic plasticity of the primary motor cortex (M1) is impaired in patients with Parkinson's disease (PD) who have developed dyskinesias. In this exploratory study, we tested whether this holds true for heterosynaptic plas ...

This manuscript serves a specific purpose: to give readers from fields such as material science, chemistry, or electronics an overview of implementing a reservoir computing (RC) experiment with her/his material system. Introductory literature on the topic ...

Spatial understanding and communication are essential skills in human interaction. An adequate understanding of others' spatial perspectives can increase the quality of the interaction, both perceptually and cognitively. In this paper, we take the first st ...

This thesis describes advances in the use of novel configurations of non-invasive brain stimulation over the visual system allowing to modulate of modifying electro-physiological activity, interregional interactions and by it, visual behavior such as motio ...

Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity of synaptic transmission. However, the mechanisms linking the two forms of homeostatic regulation have not been identified so far. Using electrophysiological, im ...

Context: Exploring the design space is an important process in a design task. In this study, we considered design space exploration for the learners in vocational education and training (VET). The goal of the study was to investigate how they explore the d ...

Human behaviour is exquisitely complex, because it is staggeringly multi-facetted and subtly varies across individuals. Characterising its yet incompletely understood underlying biological mechanisms has profound clinical implications. Here, our goal was t ...

In developed countries, the management of existing civil infrastructure is challenging due to evolving functional requirements, aging and climate change. Due to conservative approaches in construction design and practice, infrastructure often has hidden re ...

Understanding the mechanical behaviour of compacted bentonite upon re-saturation is of outmost importance in most designs of nuclear waste disposal repositories. The behaviour of bentonite is characterized by its stress-path dependency and it is typically ...

The Mind Behind the Hebbian Synapse Donald O Hebb

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Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Learnable latent embeddings for joint behavioural and neural analysis

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Principles of Network Plasticity in Neocortical Microcircuits

A theory of memory consolidation and synaptic pruning in cortical circuits

Perceived impacts of the Fridays for Future climate movement on environmental concern and behaviour in Switzerland

Engram cell connectivity as a mechanism for information encoding and memory function

Plasticity of sensory representations in the posterior insular cortex during fear learning

Lactate supply overtakes glucose when neural computational and cognitive loads scale up

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity

Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia

Hands-on reservoir computing: a tutorial for practical implementation

Do Children Adapt Their Perspective to a Robot When They Fail to Complete a Task?

Orchestration of oscillatory activity to improve visual motion discrimination

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

How Florist Apprentices Explore Bouquet Designs: Supporting Design Space Exploration for Vocational Students

Development and application of dynamic functional connectivity methods to elucidate the neural underpinnings of human behaviour with functional magnetic resonance imaging

Measurement-system design for structural identification

A numerical study on the coupled hydro-mechanical behaviour of compacted bentonite