Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

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Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...

We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the su ...

X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved concom ...

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaning-ful, and durable, standards that ensure reproducibility and ...

BackgroundIt is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or with changes in the amino acid conten ...

Adult autologous human epidermal stem cells can be extensively expanded ex vivo for cell and gene therapy. Identifying the mechanisms involved in stem cell maintenance and defining culture conditions to maintain stemness is critical, because an inadequate ...

Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-co ...

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

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Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Protein target highlights in CASP15: Analysis of models by structure providers

Species-specific regulation of XIST by the JPX/FTX orthologs

Plasticity of sensory representations in the posterior insular cortex during fear learning

ISSCR standards for the use of human stem cells in basic research

Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Bioengineering human mini-intestines with in vivo-like complexity and function

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning