Metabolic Disturbances in Diseases with Neurological Involvement

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The effects of robotic-assisted gait (RAG) training, besides conventional therapy, on neuroplasticity mechanisms and cortical integration in locomotion are still uncertain. To advance our knowledge on the matter, we determined the involvement of motor cort ...

Acute leukemia has a high mortality rate of approximately 50%, and current methods are not effective in predicting disease progression and relapse. To improve our understanding of hematopoiesis and develop new markers for predicting disease relapse in dead ...

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price. ...

Interhemispheric interactions demonstrate a crucial role for directing bimanual movement control. In humans, a well-established paired-pulse transcranial magnetic stimulation paradigm enables to assess these interactions by means of interhemispheric inhibi ...

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are ...

Considering brain structural alterations as neurodegenerative consequences of Parkinson's disease (PD), we sought to infer the progression of PD via the ordering of brain structural alterations from cross-sectional MRI observations. Having measured cortica ...

Background: Patients suffering from functional neurological disorder (FND) experience disabling neurological symptoms not caused by an underlying classical neurological disease (such as stroke or multiple sclerosis). The diagnosis is made based on reliable ...

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

Mobility impairments are a common symptom of age-related degenerative diseases. Gait features can discriminate those with mobility disorders from healthy individuals, yet phenotyping specific pathologies remains challenging. This study aims to identify if ...

In the last twenty years, advances in real-time functional magnetic resonance imaging (rt-fMRI) have offered exciting new tools to study the human brain. One of them, termed rt-fMRI neurofeedback (NF), has turned the MRI scanner environment into an interac ...

Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...

Metabolic Disturbances in Diseases with Neurological Involvement

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Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Impact of interhemispheric inhibition on bimanual movement control in young and old

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Simulating the progression of brain structural alterations in Parkinson's disease

Multi-centre classification of functional neurological disorders based on resting-state functional connectivity

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Gait Variability to Phenotype Common Orthopedic Gait Impairments Using Wearable Sensors

Real-Time fMRI Neurofeedback: Methods and Application to Chronic Tinnitus

Dissecting the role of the mitochondrial carrier SLC25A47