Publication

Memristive Aptasensors for Theranostics

Publications associées (29)

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

Thomas Lehnert, Martinus Gijs, Matteo Cornaglia

In a typical high-throughput drug screening (HTS) process, up to millions of chemical compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit a robust dose-response, as evidenced for example by a fluorescence signal. I ...

Royal Soc Chemistry2017

Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer

Maria Soler Aznar

Colorectal cancer is treatable and curable when detected at early stages. However there is a lack of less invasive and more specific screening and diagnosis methods which would facilitate its prompt identification. Blood circulating autoantibodies which ar ...

Elsevier Science Bv2016

Screening Materials Relevant for Energy Technologies

Berend Smit

In this short review, some recent advances are discussed in the development of computational techniques to perform large-scale screening of materials for energy-related applications. We focus on carbon capture and methane storage in different classes of na ...

Schweizerische Chemische Gesellschaft2015

Exploring Ligand Affinities for Proteins by NMR of Long-Lived States

Roberto Buratto

The detection of molecules that can bind to active sites of protein targets and the measurement of their affinities is a promising application of NMR. Nowadays, the screening of drug candidates is routinely done by NMR in pharmaceutical industry. We have p ...

EPFL2015

Nanosensors for early cancer detection and for therapeutic drug monitoring

Francesco Stellacci

The use of nanotechnology for drug delivery in cancer therapy has raised high expectations. Additionally, the use of nanomaterials in sensors to extract and detect tumor specific biomarkers, circulating tumor cells, or extracellular vesicles shed by the tu ...

Future Medicine2015

Tuberculosis drug discovery in the post-post-genomic era

Stewart Cole, Benoit Lechartier, Jan Lars Rybniker

The expectation that genomics would result in new therapeutic interventions for infectious diseases remains unfulfilled. In the post-genomic era, the decade immediately following the availability of the genome sequence of Mycobacterium tuberculosis, tuberc ...

Wiley Open Access2014

Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland

Gerardo Turcatti

The Biomolecular Screening Facility (BSF) is a multidisciplinary laboratory created in 2006 at the Ecole Polytechnique Federale de Lausanne (EPFL) to perform medium and high throughput screening in life sciences-related projects. The BSF was conceived and ...

Bentham Science Publishers2014

Sensitivity Analysis of a Bottom Reflood Simulation using Morris Screening Method

Damar Canggih Wicaksono, Andreas Pautz, Omar Zerkak

In the work presented in this paper, a sensitivity analysis using the Morris screening method was carried out for a model of the Flooding Experiment with Blocked Arrays (FEBA) separate-effect test facility. The sensitivity analysis was conducted in the con ...

2014

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

Gerardo Turcatti, Christian Depeursinge, Marc Chambon, Jonas Kühn, Pierre Magistretti, Benjamin Rappaz, Julien Mena, Jérôme Parent, Etienne Shaffer

We introduce a label-free technology based on digital holographic microscopy (DHM) with applicability for screening by imaging, and we demonstrate its capability for cytotoxicity assessment using mammalian living cells. For this first high content screenin ...

Mary Ann Liebert2013