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We explore the sum over topologies in \mathrm{AdS}_3 quantum gravity and its relationship with the statistical interpretation of the boundary theory. We formulate a statistical version of the conformal bootstrap that systematizes the universal statistical properties of high-energy CFT _2 data. We identify a series of surgery moves on bulk manifolds that precisely reflect the requirements of typicality and crossing symmetry of the boundary ensemble. These surgery moves generate a large number of bulk manifolds that have to be included in any reasonable definition of the gravitational path integral. We show that this procedure generates only on-shell (hyperbolic) manifolds, although it does not produce all of them. These proofs rely on structure theorems of 3-manifolds, which non-trivially interact with the requirements of the statistical boundary ensemble. We illustrate the application of this procedure with many examples, such as Euclidean wormholes, twisted I -bundles and handlebody-knots. Our findings reveal a large space of possible choices of which manifolds can be included in the gravitational path integral, reflecting a wide range of possible statistical ensembles consistent with crossing symmetry and typicality.