Publication

It's All in the Eyes: Subcortical and Cortical Activation during Grotesqueness Perception in Autism

Publications associées (30)

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, g ...

Amer Assoc Advancement Science2024

Driving and suppressing the human language network using large language models

Martin Schrimpf

Transformer models such as GPT generate human-like language and are predictive of human brain responses to language. Here, using functional-MRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model can predict t ...

Nature Portfolio2024

Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Nada Kojovic, Farnaz Delavari

The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns ( ...

Wiley2024

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Maria del Carmen Sandi Perez, Elias Georges Gebara, Ana del Rocio Conde Moro

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Springer2024

The mouse motor system contains multiple premotor areas and partially follows human

Joanes Grandjean, Valerio Zerbi

While humans are known to have several premotor cortical areas, secondary motor cortex (M2) is often considered to be the only higher -order motor area of the mouse brain and is thought to combine properties of various human premotor cortices. Here, we sho ...

Cell Press2024

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Emilie Cornelia Maria Revol

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

EPFL2024

Probing and modulating inter-areal coupling in the cortical visual motion processing pathway with non-invasive brain stimulation

Michele Bevilacqua

In the last few years, stroke ranked as the second most common cause of death and is the third most significant condition affecting disability-adjusted life years (DALYs) worldwide. Being the most prevalent and quality of life impacting post-stroke symptom ...

EPFL2024

Social isolation shortens lifespan through oxidative stress in ants

Alessandro Crespi, Laurent Keller

Social isolation negatively affects health, induces detrimental behaviors, and shortens lifespan in social species. Little is known about the mechanisms underpinning these effects because model species are typically short-lived and non-social. Using coloni ...

Nature Research2023

Event-related causality in stereo-EEG discriminates syntactic processing of noun phrases and verb phrases

Silvestro Micera, Fiorenzo Artoni

Objective. Syntax involves complex neurobiological mechanisms, which are difficult to disentangle for multiple reasons. Using a protocol able to separate syntactic information from sound information we investigated the neural causal connections evoked by t ...

IOP Publishing Ltd2023

Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas

Anastasiia Oryshchuk

An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...

EPFL2023

Early motor skill acquisition in healthy older adults: brain correlates of the learning process

Manon Chloé Durand-Ruel, Pablo Maceira Elvira, Friedhelm Christoph Hummel, Takuya Morishita, Maeva Moyne, Chang-Hyun Park

Motor skill learning is a crucial process at all ages. However, healthy aging is often accompanied by a reduction in motor learning capabilities. This study characterized the brain dynamics of healthy older adults during motor skill acquisition and identif ...

OXFORD UNIV PRESS INC2023

Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions

Silvestro Micera, Maria Pasquini

Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, timing and pattern of activation of GABAergic cells during specific motor behaviors remain only partly unde ...

SOC NEUROSCIENCE2023

Noninvasive deep brain stimulation to modulate human behavior by means of transcranial temporal interference electrical stimulation

Elena Beanato

All functions we use in our everyday life depend on a complex interplay between both cortical and subcortical brain areas, communicating in between each others. When a region is affected by either an accident, aging or neurodegenerative diseases, the whole ...

EPFL2023

Combined use of intraoperative MRI and awake tailored microsurgical resection to respect functional neural networks: preliminary experience

Constantin Tuleasca

INTRODUCTION: The combined use of intraoperative MRI and awake surgery is a tailored microsurgical resection to respect functional neural networks (mainly the language and motor ones). Intraoperative MRI has been classically considered to increase the exte ...

2023

Emotional sounds in space: asymmetrical representation within early-stage auditory areas

Stephanie Clarke

Evidence from behavioral studies suggests that the spatial origin of sounds may influence the perception of emotional valence. Using 7T fMRI we have investigated the impact of the categories of sound (vocalizations; non-vocalizations), emotional valence (p ...

FRONTIERS MEDIA SA2023

Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait

Silvestro Micera, Fiorenzo Artoni

The effects of robotic-assisted gait (RAG) training, besides conventional therapy, on neuroplasticity mechanisms and cortical integration in locomotion are still uncertain. To advance our knowledge on the matter, we determined the involvement of motor cort ...

Nature Portfolio2023

Plasticity of sensory representations in the posterior insular cortex during fear learning

Denys Osypenko

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

EPFL2023

Convolutional neural network classifies visual stimuli from cortical response recorded with wide-field imaging in mice

Silvestro Micera, Daniela De Luca

Objective. The optic nerve is a good location for a visual neuroprosthesis. It can be targeted when a subject cannot receive a retinal prosthesis and it is less invasive than a cortical implant. The effectiveness of an electrical neuroprosthesis depends on ...

IOP Publishing Ltd2023

Connecting the dots: harnessing dual-site transcranial magnetic stimulation to quantify the causal influence of medial frontal areas on the motor cortex

Pierre Theopistos Vassiliadis

Dual-site transcranial magnetic stimulation has been widely employed to investigate the influence of cortical structures on the primary motor cortex. Here, we leveraged this technique to probe the causal influence of two key areas of the medial frontal cor ...

Oxford Univ Press Inc2023

The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample

Charles Laidi, Farnaz Delavari

Multiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar stru ...

Springer2023