Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

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Mechanistic classification and benchmarking of polyolefin depolymerization over silica-alumina-based catalysts

Jed Russell Carullo, Paul Joseph Dyson, Mounir Driss Mensi, Felix Daniel Bobbink, Antoine Philippe Van Muyden, Wei-Tse Lee

Carbon-carbon bond cleavage mechanisms play a key role in the selective deconstruction of alkanes and polyolefins. Here, we show that the product distribution, which encompasses carbon range and formation of unsaturated and isomerization products, serves a ...

Nature Research2022

Attacks on some post-quantum cryptographic protocols: The case of the Legendre PRF and SIKE

Novak Kaluderovic

Post-quantum cryptography is a branch of cryptography which deals with cryptographic algorithms whose hardness assumptions are not based on problems known to be solvable by a quantum computer, such as the RSA problem, factoring or discrete logarithms. This ...

EPFL2022

Key challenges for tropospheric chemistry in the Southern Hemisphere

Julia Schmale

This commentary paper from the recently formed International Global Atmospheric Chemistry (IGAC) Southern Hemisphere Working Group outlines key issues in atmospheric composition research that particularly impact the Southern Hemisphere. In this article, we ...

2022

Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

Aortic compliance is an important determinant of cardiac afterload and a contributor to cardiovascular morbidity. In the present study, we sought to provide in silico insights into the acute as well as long-term effects of aortic compliance decrease on cen ...

FRONTIERS MEDIA SA2021

The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

Ventricular-arterial coupling is a major determinant of cardiovascular performance, however, there are still inherent difficulties in distinguishing ventricular from vascular effects on arterial pulse phenotypes. In the present study, we employed an extens ...

2021

Vibration monitoring based on optical sensing of mechanical nonlinearities in glass suspended waveguides

Yves Bellouard, Tao Yang, Pieter Vlugter, Enrico Casamenti

Vibration monitoring plays a key role in numerous applications, including machinerypredictive maintenance, shock detection, space applications, packaging-integrity monitoring andmining. Here, we investigate mechanical nonlinearities inherently present in s ...

2021

On the assessment of arterial compliance from carotid pressure waveform

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

In a progressively aging population, it is of utmost importance to develop reliable, noninvasive, and cost-effective tools to estimate biomarkers that can be indicative of cardiovascular risk. Various pathophysiological conditions are associated to changes ...

AMER PHYSIOLOGICAL SOC2021

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

Hilal Lashuel, Grégoire Millet, Johannes Burtscher, Muhammed Muazzam Kamil Syed

Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how ne ...

WILEY2021

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

Vasiliki Bikia

In a progressively aging population, it is of utmost importance to develop reliable, non-invasive, and cost-effective tools to estimate biomarkers that can be indicative of cardiovascular risk. Clinical parameters directly measured in the heart or the aort ...

EPFL2021

Automated Design: A Journey Across Modelling, Optimization, and Education

Cyril Picard

Machine intelligence greatly impacts almost all domains of our societies. It is profoundly changing the field of mechanical engineering with new technical possibilities and processes. The education of future engineers also needs to adapt in terms of techni ...

EPFL2021

Are Functional Measures Sufficient to Capture Acceptance? A Qualitative Study on Lower Limb Exoskeleton Use for Older People

Mohamed Bouri

Lower limb exoskeletons (LLE) are robotic devices developed to assist walk. In the field of healthcare, this technology has been available for almost a decade, yet it still faces important acceptance issues. While LLE were first developed for patients with ...

SPRINGER2022

Structural Order of the Molecular Adlayer Impacts the Stability of Nanoparticle-on-Mirror Plasmonic Cavities

Christophe Marcel Georges Galland, Magalí Alejandra Lingenfelder, Sachin Suresh Verlekar, Karla Banjac, Aqeel Ahmed, Fernando Pablo Cometto

Immense field enhancement and nanoscale confinement of light are possible within nanoparticle-on-mirror (NPoM) plasmonic resonators, which enable novel optically activated physical and chemical phenomena and render these nanocavities greatly sensitive to m ...

AMER CHEMICAL SOC2021