Publication

Contribution of polymeric materials to progress in xenotransplantation of microencapsulated cells - A review

Publications associées (23)

Biocompatible and Biodegradable 3D Printing from Bioplastics: A Review

There has been a lot of interest in developing and producing biodegradable polymers to address the current environmental problem caused by the continued usage of synthetic polymers derived from petroleum products. Bioplastics have been identified as a poss ...

MDPI2023

Phase behaviour and structure of a model biomolecular condensate

Julian Charles Shillcock

Phase separation of immiscible fluids is a common phenomenon in polymer chemistry, and is recognized as an important mechanism by which cells compartmentalize their biochemical reactions. Biomolecular condensates are condensed fluid droplets in cells that ...

2020

Functional and Responsive Polymers via Controlled Radical Polymerization

Jian Wang

This Thesis is built around 4 topics, which share in common that they all take advantage of the assets of controlled radical polymerization to either (i) prepare well-defined model systems to address fundamental research questions with regard to the sensit ...

EPFL2020

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Polymer-theory insights into biomolecular systems

Salvatore Assenza

Boosted by the technological advances in experimental techniques, cellular biology is nowadays facing the need for quantitative approaches in order to rationalize the huge amount of collected data. A particularly succesfull theoretical framework is provide ...

EPFL2015

Peptide-Polymer Conjugates for Therapeutic Applications

Ana Maria Raduta

Over the last ten years the attention of the pharmaceutical industry has shifted away from small molecules to focus on new biologics such as antibodies, proteins and therapeutic peptides. Herein, peptides have emerged as a particularly interesting category ...

EPFL2015

Cell Compatible Arginine Containing Cationic Polymer: One-Pot Synthesis and Preliminary Biological Assessment

Jutta Christine Wandrey, Lucia Baldi Unser, Xiao Shen, Nino Zavradashvili, Tamar Memanishvili

Synthetic cationic polymers are of interest as both nonviral vectors for intracellular gene delivery and antimicrobial agents. For both applications synthetic polymers containing guanidine groups are of special interest since such kind of organic compounds ...

Springer India2014

Squaric acid mediated bioconjugation expanded to polymers prepared by ATRP

Harm-Anton Klok, Frederik Roman Wurm

The squaric acid mediated bioconjugation reaction is an attractive approach for the amine-selective protein modification with side-chain functional polymers. This manuscript presents 3 squaric acid based atom transfer radical polymerization (ATRP) initiato ...

Royal Soc Chemistry2014

Squaric Acid Mediated Synthesis and Biological Activity of a Library of Linear and Hyperbranched Poly(Glycerol)-Protein Conjugates

Harm-Anton Klok, Frederik Roman Wurm

Polymer-protein conjugates generated from side chain functional synthetic polymers are attractive because they can be easily further modified with, for example, labeling groups or targeting ligands. The residue specific modification of proteins with side c ...

American Chemical Society2012

Hybrid Polymer Foams for Osteochondral Tissue Engineering

Matthieu Cuénoud

Articular cartilage is a soft tissue that covers the ends of articulating bones, and is essential for maintaining joint motion, i.e. translation and rotation between the bones. Articular cartilage nevertheless has a limited capacity for self-repair, and ca ...

EPFL2012

Combating HIV Type 1 with Peptide - Synthetic Polymer Conjugates

Maarten Danial

Polymer therapeutics is a class of (bio)hybrid materials that include a plethora of biologically active (synthetic) macromolecules that either consist of polymeric drugs, drug-polymer conjugates, peptide/protein-polymer conjugates or of drug, peptide or pr ...

EPFL2011

A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes

Jeffrey Alan Hubbell, Harm-Anton Klok, Brian Pullin

This manuscript reports a facile strategy for the modification of polyethylene, a widely used biomaterial, with a thin non-biofouling coating that can act as a platform to introduce biochemical cues to control and direct, e.g., cell adhesion and proliferat ...

Wiley-Blackwell2010

Arrays of EAP micro-actuators for single-cell stretching applications

Herbert Shea, Samin Akbari

Mechanical stimuli are critical for the development and maintenance of most tissues such as muscles, cartilage, bones and blood vessels. The commercially available cell culture systems replicating the in vivo environment are typically based on simple membr ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2010

Peptide/Protein−Synthetic Polymer Conjugates: Quo vadis

Harm-Anton Klok

Peptide/protein-synthetic polymer conjugates, which covalently combine one or more copies of a peptide sequence or protein with one or more synthetic polymer elements. offer unique possibilities to integrate the properties and functions of bio(macro)molecu ...

American Chemical Society2009

Studies on scaffold design for tissue engineering applications : contribution of synthetic, natural and recombinant materials

The aim of tissue engineering is to regenerate tissue for the purpose of repairing or replacing diseased or injured tissue. Therefore, cells that are able to proliferate are seeded on scaffolds that provide mechanical stability and direct the three-dimensi ...

EPFL2009

Initial In Vivo Studies with a Polymer-based MR-compatible Guide Wire

The purpose of this study was to evaluate a new polymer-based and magnetic resonance (MR) imaging-compatible guide wire for its application in MR-guided endovascular interventions, particularly for interventional peripheral MR angiography in swine experime ...

Elsevier2009

Peptide/protein – polymer conjugates: synthetic strategies and design concepts

Harm-Anton Klok, Marc Gauthier

This feature article provides a compilation of tools available for preparing well-defined peptide/protein–polymer conjugates, which are defined as hybrid constructs combining (i) a defined number of peptide/protein segments with uniform chain lengths and d ...

Royal Society of Chemistry2008

Solution behavior of peptide and peptide-hybrid materials

Harald Nuhn

Peptide based and peptide hybrid materials represent two interesting and challenging classes of biomaterials. Both classes consist of and contain, respectively, one or more polypeptide blocks, endowing the resulting polymers with enhanced self-assembly pro ...

EPFL2008

Superparamagnetic iron oxide nanoparticles (SPIONs): from synthesis to in vivo studies - A summary of the synthesis, characterization, in vitro and in vivo investigations of SPIONs with particular focus on surface and colloidal properties

Heinrich Hofmann, Alke Fink

In this work, we present a short summary of the synthesis and characterization of superparamagnetic iron oxide nanoparticles and their behavior in vitro and in vivo. Therefore, we have used various characterization techniques to deduce the physical particl ...

2007

Magnetic and electrostatic effects on the polymerization of water-soluble monomers

Ignacio Rintoul

Free radical polymerization is the most frequently used technique to produce synthetic polymers. They represent more than 25% of the total volume of materials made by the mankind. 3% thereof correspond to water soluble polymers with annual growth rates est ...

EPFL2006