Publications associées à Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine

Publications associées (15)

Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadly type of cancer, with an extremely low five-year overall survival rate. To date, current treatment options primarily involve various chemotherapies, which often prove ineffecti ...

Springer Science and Business Media LLC2025

The physical roles of different posterior tissues in zebrafish axis elongation

Sangwoo Kim

Shaping embryonic tissues requires spatiotemporal changes in genetic and signaling activity as well as in tissue mechanics. Studies linking specific molecular perturbations to changes in the tissue physical state remain sparse. Here we study how specific g ...

NATURE PORTFOLIO2025

Microfabrication of lipids for drug delivery applications

Jongeon Park

All living organisms contain lipids because lipids are the essential components of cell membranes, which preserve the integrity and functionality of cells by protecting their organelles from the external environment. Lipids can also be found easily in our ...

EPFL2025

Molecular characterization of an adhesion GPCR signal transduction using Graph-neural networks

Matthieu François Marfoglia

Key cellular functions depend on the transduction of extracellular mechanical signals by specialized membrane receptors, including adhesion G-protein coupled receptors (aGPCRs). While recent structural studies support aGPCR activation through shedding of t ...

EPFL2025

A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging

Sara Ancel

Increasing evidence suggests that the muscle stem cell (MuSC) pool is heterogeneous. In particular, a rare subset of PAX7-positive MuSCs that has never expressed the myogenic regulatory factor MYF5 displays unique self-renewal and engraftment characteristi ...

2024

Supplementary files for Machine learning for histological annotation and quantification of cortical layers

Olivier Burri, Julie Meystre

Creators Meystre Julie Olivier Burri Contributors Jean Jacquemier Description This dataset contains 7 QuPath projects. The raw data images linked to these projects and located in other Zenodo datasets need to be downloaded as well. The raw data contains im ...

Zenodo2024

Can you Teach Cell Biology using Computer Simulations?

Julian Charles Shillcock

Computational modelling is important in the life sciences, but students may not be greatly exposed to it in typical curricula.This paper describes an innovative, one-semester Master's level course in cell biology that uses computer simulations as the prima ...

European Society for Engineering Education (SEFI)2024

Computer-aided design and implementation of efficient biosynthetic pathways to produce high added-value products derived from tyrosine in Escherichia coli

Vassily Hatzimanikatis, Anastasia Sveshnikova

Developing efficient bioprocesses requires selecting the best biosynthetic pathways, which can be challenging and time-consuming due to the vast amount of data available in databases and literature. The extension of the shikimate pathway for the biosynthes ...

2024

Rational design of small-molecule responsive protein switches

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Sailan Shui, Stephen Michael Buckley

Small-molecule responsive protein switches are powerful tools for controlling cellular processes. These switches are designed to respond rapidly and specifically to their inducer. They have been used in numerous applications, including the regulation of ge ...

2023

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Johan Auwerx, Olaia Maria Naveiras Torres-Quiroga, Frédérica Schyrr, Charles Christopher Bataclan

Aging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During agin ...

SPRINGERNATURE2023

Passive transport of Ca2+ ions through lipid bilayers imaged by widefield second harmonic microscopy

Sylvie Roke, David Roesel, Maksim Eremchev

In biology, release of Ca2+ ions in the cytosol is essential to trigger or control many cell functions. Calcium signaling acutely depends on lipid membrane permeability to Ca2+. For proper understanding of membrane permeability to Ca2+, both membrane hydra ...

2023

A multi-objective planning method for multi-energy complementary distributed energy system: Tackling thermal integration and process synergy

François Maréchal, Hangyu Yu

This study proposes a multi-objective optimization methodology for planning multi-energy complementary distributed energy systems considering process synergy and thermal integration. The process integration tech-nique is integrated into the Energy Hub mode ...

ELSEVIER SCI LTD2023

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Didier Trono, Priscilla Turelli, Alexandre Louis André Persat, Julien Léonard Duc, Alexandre Coudray, Michaël Imbeault, Tamara Rossy, Delphine Yvette L Grun, Alexandra Iouranova, Jonas Caspar De Tribolet-Hardy

Background Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to g ...

2022

c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs

Matthias Lütolf, Jakob Josef Langer

c-MAF, highly expressed in villus small intestinal enterocytes, coordinates transcriptional programs for nutrient absorption. Enterocyte-specific c-MAF inactivation impairs dietary lipid handling but also leads to tuft cell expansion and adaptive gut lengt ...

ROCKEFELLER UNIV PRESS2022

Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Jacques Fellay, Konstantin Popadin, Christian Axel Wandall Thorball

People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition an ...

Nature Portfolio2022