Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers

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Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity

Andrea Cavalli

The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue fo ...

SPRINGERNATURE2025

Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression

Stephan Morgenthaler

Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC deaths can be reduced with prevention and early diagnosis. Circulating tumor DNA-based liquid biopsies, are emerging tools for cancer detection. However, ...

2024

Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Pierre Vogel, Florence Pojer, Somi Reddy Majjigapu, Aline Emma Christine Reynaud

The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in t ...

TAYLOR & FRANCIS LTD2022

DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis

Andrea Ablasser

DNA methylation is a fundamental epigenetic modification, important across biological processes. The maintenance methyltransferase DNMT1 is essential for lineage differentiation during development, but its functions in tissue homeostasis are incompletely u ...

WILEY2021