Microfluidics-generated immobilized biomolecule gradients on hydrogels

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No T cell receptor (TCR) T cell therapies have obtained clinical approval. The lack of strategies capable of selecting and recovering potent T cell candidates may be a contributor to this. Existing protocols for selecting TCR T cell clones for cell therapi ...

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A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a ...

Tissues morphogenesis and homeostasis involve the spatiotemporal regulation of mechanics at multiple scales. Characterization of mechanical properties of biological systems as well as investigating the effects of mechanical forces on biological function ar ...

Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...

Our aim is to develop a 3D model unit of cardiac muscle: an in-vitro analog of the trabeculae carneae found in vivo. As a base hydrogel matrix for cardiomyocyte culture in 3D, we develop a blend of decellularized extracellular matrix (dECM) and fibrin. Thi ...

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Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases at the intersection of health and disease due to their involvement in processes such as tissue repair and immunity as well as cancer and inflammation. Because of the high structural conserv ...

Tissue decellularisation has gained much attention in regenerative medicine as an alternative to synthetic materials. In decellularised tissues, biological cues can be maintained and provide cellular environments still unmet by synthetic materials. Supercr ...

Microfluidics-generated immobilized biomolecule gradients on hydrogels

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Microfluidic T Cell Selection by Cellular Avidity

Organoids as tools for fundamental discovery and translation-A Keystone Symposia report

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Wireless soft microscale actuators and robotic devices to study mechanobiology

Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology

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Mechanical principles of engineering fibrous tissues with programmable shape

Engineered peptide macrocycles can inhibit matrix metalloproteinases with high selectivity

Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2