Editorial: Regional and molecular fingerprint of adipogenesis in aging and disease

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Understanding the interplay between cell fate specification and morphogenetic changes remains a challenge in developmental biology. Gastruloids, stem cell models of postimplantation mammalian development, provide a platform to address this question. Here, ...

Organellophagy receptors control the generation and delivery of portions of their homing organelle to acidic degradative compartments to recycle nutrients, remove toxic or aged macromolecules and remodel the organelle upon physiologic or pathologic cues. H ...

Glioblastoma recurrence is currently inevitable despite extensive standard-of-care treatment. In preclinical studies, an alternative strategy of targeting tumor-associated macrophages and microglia through CSF-1R inhibition was previously found to regress ...

The regulation of energy in the brain has garnered substantial attention in recent years due to its significant implications in various disorders and aging. The brain’s energy metabolism is a dynamic and tightly regulated network that balances energy deman ...

Proteins are fundamental biomolecules in living organisms, performing diverse functions through intricate interactions with their environment. Understanding these interactions is crucial not only for elucidating normal biological processes, but also for un ...

Cellular contractility, migration, and extracellular matrix (ECM) mechanics are critical for a wide range of biological processes including embryonic development, wound healing, tissue morphogenesis, and regeneration. Even though the distinct response of c ...

For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the potential neurotoxicity of chemicals before their release in the market, needs to be replaced by new approach methodologies. To illustrate the use of new approach ...

Nicotinamide riboside (NR) is a form of vitamin B3 and is one of the most studied compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in many metabolic and age-related disorders. Despite its wide commercial availability a ...

We highlight papers by Diaz-Cuadros et al.(1) and Iwata et al.(2) that demonstrate the role of mitochondrial metabolism in setting developmental pace through their control over cellular bioenergetics and redox homeostasis in mice and humans. ...

Walking with a shorter stride length (SL) was recently proposed for gait retraining in medial knee osteoarthritis; however it was never assessed in this patient population. This study tested the hypothesis that shortening SL while maintaining walking speed ...

Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage p ...

Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but in vivo studies on this matter remain sparse and have repo ...

Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ phy ...

Glucose is a major energy fuel for the brain, however, less is known about specificities of its metabolism in distinct cerebral areas. Here we examined the regional differences in glucose utilization between the hypothalamus and hippocampus using in vivo i ...

The authors have developed a live-cell multimodality microscope combining epifluorescence with digital holographic microscopy; it has been implemented with a decoupling procedure allowing to separately measure from the quantitative phase important cell par ...

Editorial: Regional and molecular fingerprint of adipogenesis in aging and disease

Chattez avec Graph Search

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Harboring CAR-T cells using an injectable scaffold to treat solid tumors

Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence

Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes

Study of disease-associated proteins using integrative structural biology: the case of GOLPH3 and PREPL

Modeling the mechanosensitive collective migration of cells on the surface and the interior of morphing soft tissues

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD plus metabolism

Mitochondria: A "pacemaker"for species-specific development

Walking with shorter stride length could improve knee kinetics of patients with medial knee osteoarthritis

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses

In Vivo Metabolism of [1,6-C-13(2)]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus

Combination of neonatal porcine islets with mesenchymal stem cells of human and porcine origin improves islet function

Expanding the druggable proteome: Ligand and target discovery by fragment-based screening in cells

Metal-based Drugs

Cell Morphology and Intracellular Ionic Homeostasis explored with a Multimodal Approach combining Epifluorescence and Digital Holographic Microscopy

Posttranslational covalent labeling reveals heterogeneous mobility of individual G protein-coupled receptors in living cells