Full System for Translational Studies of Personalized Medicine with Free-Moving Mice (invited)

A full remotely powered system for metabolism monitoring of free-moving mice is presented here. The fully implantable sensing platform hosts two ASICs, one off-the-shelf micro-controller, four biosensors, two other sensors, a coil to receive power, and an antenna to transmit data. Proper enzymes ensure specificity for animal metabolites while Multi-Walled Carbon Nanotubes ensure the due sensitivity. The remote powering is indeed provided by inductive coils located under the floor of the mouse' cage. Two different approaches were investigated to ensure freedom of movement to the animal. The application to studies for personalized medicine is demonstrated by showing continuous monitoring of both glucose and paracetamol.