Publications associées à Zebrafish: Housing and husbandry recommendations

A Robotic Surgery Platform for Automated Tissue Micromanipulation in Zebrafish Embryos

Mahmut Selman Sakar, Ece Özelçi, Andrew Charles Oates, Laurel Ann Rohde, Erfan Etesami

Microsurgical manipulations are key experimental techniques in life science research, particularly in embryology. These techniques are most often performed manually by highly skilled scientists, posing limitations on speed, precision, and reproducibility. ...

2024

Photobiology and metabolic interactions in the symbiotic jellyfish Cassiopea

Niclas Heidelberg Lyndby

The symbiont-bearing jellyfish Cassiopea live a benthic lifestyle, positioning themselves upside-down on sediments in shallow waters to allow their endosymbiotic algae to photosynthesize in the sunlight. Over the last decades Cassiopea has become increasin ...

EPFL2023

Incomplete Recovery of Zebrafish Retina Following Cryoinjury

Dylan Lawless

Zebrafish show an extraordinary potential for regeneration in several organs from fins to central nervous system. Most impressively, the outcome of an injury results in a near perfect regeneration and a full functional recovery. Indeed, among the various i ...

MDPI2022

Approaches to Test the Neurotoxicity of Environmental Contaminants in the Zebrafish Model: From Behavior to Molecular Mechanisms

Anze Zupanic, Sarah-Katharina Könemann, Colette vom Berg

The occurrence of neuroactive chemicals in the aquatic environment is on the rise and poses a potential threat to aquatic biota of currently unpredictable outcome. In particular, subtle changes caused by these chemicals to an organism's sensation or behavi ...

2021

Modeling spinal locomotor circuits for movements in developing zebrafish

Yann Roussel

Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively b ...

eLIFE SCIENCES PUBL LTD2021

Deformation-aware Unpaired Image Translation for Pose Estimation on Laboratory Animals

Pascal Fua, Pavan P Ramdya, Helge Jochen Rhodin, Semih Günel, Mirela Ostrek, Siyuan Li

Our goal is to capture the pose of neuroscience model organisms, without using any manual supervision, to be able to study how neural circuits orchestrate behaviour. Human pose estimation attains remarkable accuracy when trained on real or simulated datase ...

2020

FELASA accreditation of education and training courses in laboratory animal science according to the Directive 2010/63/EU

Marcel Gyger

This document describes how the Federation of European Laboratory Animal Science Associations (FELASA) accreditation addresses both the Directive 2010/63/EU and the related European Commission guidance document. The four EU Functions and beyond: FELASA acc ...

2019

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

Imidacloprid induces adverse effects on fish early life stages that are more severe in Japanese medaka (Oryzias latipes) than in zebrafish (Danio rerio)

Kristin Schirmer, Juliane Hollender

Neonicotinoids are widely used insecticides that have frequently been found in freshwater with concentrations ranging from ng to mu g/L. It is known that these compounds impact non-target invertebrates, such as bees and gammaridae, in terms of toxicity and ...

Pergamon-Elsevier Science Ltd2019

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

Raphael Christopher Sommer

Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious agent, claiming 1.6 million human lives and causing >10 million new cases in 2017 alone, mostly in low-income regions. The intracellular pathogen Mycobacterium tuberculos ...

EPFL2019

A generalised framework for detailed classification of swimming paths inside the Morris Water Maze

Maria del Carmen Sandi Perez, Eleni Vasilaki

The Morris Water Maze is commonly used in behavioural neuroscience for the study of spatial learning with rodents. Over the years, various methods of analysing rodent data collected during this task have been proposed. These methods span from classical per ...

Nature Research2018

Alternative Approaches to Vertebrate Ecotoxicity Tests in the 21st Century: A Review of Developments Over the Last 2 Decades and Current Status

Kristin Schirmer

The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unne ...

Wiley-Blackwell2016

Design Methods for Miniature Underwater Soft Robots

Francesco Mondada, Daniel Burnier, Frank Bonnet, Norbert Crot

A robotic fish accepted by animals as conspecifics is a very powerful tool in behavioral biology. To obtain the acceptance of the device towards the animals, it should generate some visual stimuli that can be perceived by a living fish as attractive signal ...

Ieee2016

Infiltrating the Zebrafish Swarm: Design, Implementation and Experimental Tests of a Miniature Robotic Fish Lure for Fish-Robot Interaction Studies

Francesco Mondada, Frank Bonnet, Yuta Kato

Robotic fish are nowadays developed for various types of research, such as bio-inspired robotics, biomimetics and animal behavior studies. In the context of our research on the social interactions of the zebrafish Danio Rerio, we developed a miniature robo ...

Springer2015

Investigating Alternatives To The Fish Early-Life Stage Test: A Strategy For Discovering And Annotating Adverse Outcome Pathways For Early Fish Development

Kristin Schirmer

The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical manag ...

Wiley-Blackwell2014

Social Adaptation of Robots for Modulating Self-Organization in Animal Societies

Francesco Mondada, Frank Bonnet, Marcelo Elias de Oliveira, Robert Matthew Mills

The goal of the work presented here is to influence the overall behaviour of specific animal societies by integrating computational mechatronic devices (robots) into those societies. To do so, these devices should be accepted by the animals as part of the ...

IEEE2014

Functional analysis of NR2E3 in retinal degenerations

The vertebrate retina is a model system of the development of the central nervous system. Because of its rapid development and the availability of many molecular tools the zebrafish is an established model of retinal development. Development and maintenanc ...

EPFL2014

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

Kristin Schirmer

Tests with vertebrates are an integral part of environmental hazard identification and risk assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed additives and effluents. These tests raise ethical and economic concerns and are ...

Academic Press Inc Elsevier Science2013

Soft Robot for Gait Rehabilitation of Spinalized Rodents

Silvestro Micera, Jamie Paik, Grégoire Courtine, Yi Sun, Joachim von Zitzewitz, Rubia van den Brand, Yun Seong Song

Soft actuators made of highly elastic polymers allow novel robotic system designs, yet application-specific soft robotic systems are rarely reported. Taking notice of the characteristics of soft pneumatic actuators (SPAs) such as high customizability and l ...

Ieee2013