Development of multivalent FAP-targeted Small Molecule-Drug Conjugates with tailored MMAE release kinetics

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Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

MYC-driven group-3 medulloblastomas (MBs) are malignant pediatric brain cancers without cures. To define actionable metabolic dependencies, we identify upregulation of dihydrolipoyl transacetylase (DLAT), the E2-subunit of pyruvate dehydrogenase complex (P ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases for which chemotherapy has not been very successful yet. FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide) is a well-known NAMPT (nicotinamide phosphoribos ...

Breast cancer is the most common cancer in women worldwide, with an estimated 1.7 million newly diagnosed cases in 2012. Despite the many clinical manifestations, metastatic disease is the main cause of death, and is responsible for 90% of all breast cance ...

Development of multivalent FAP-targeted Small Molecule-Drug Conjugates with tailored MMAE release kinetics

Chattez avec Graph Search

Trajectories of macrophage ontogeny and reprogramming in cancer

Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer