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Multi-motif scaffolding for de novo pathogen antigen mimetics by deep generative learning

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Publications associées (25)

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Automated Ensemble Multimodal Machine Learning for Healthcare

Lucas Salomon Brunschwig

The application of machine learning in medicine and healthcare has led to the creation of numerous diagnostic and prognostic models. However, despite their success, current approaches generally issue predictions using data from a single modality. This stan ...

2025

Adaptive Test-Time Learning Under Domain Shift: From Augmentation to Prolonged Adaptation

Devavrat Tomar

Deep neural networks often fail to generalize when deployed in dynamic and unpredictable real-world environments, where data distributions at test time can differ significantly from those encountered during training. Since simulating all possible distribut ...

EPFL2025

Solving the Cold-Start Problem for the Edge: Clustering and Adaptive Deep Learning for Emotion Detection

José Angel Miranda Calero

Designing AI-based applications personalized to each user's behavior presents significant challenges due to the cold start problem and the impracticality of extensive individual data labeling. These challenges are further compounded when deploying such app ...

IEEE2025

Non-asymptotic performance of social machine learning under limited data

Ali H. Sayed, Virginia Bordignon, Mert Kayaalp, Ping Hu

This paper studies the probability of error associated with the social machine learning framework, which involves an independent training phase followed by a cooperative decision-making phase over a graph. This framework addresses the problem of classifyin ...

2025

Accelerating MoE Model Inference with Expert Sharding

André Loureiro Espírito Santo, Anne-Marie Kermarrec, Rafael Pereira Pires, Marinus Abraham de Vos, Milos Vujasinovic

Mixture of experts (MoE) models achieve state-of-the-art results in language modeling but suffer from inefficient hardware utilization due to imbalanced token routing and communication overhead. While prior work has focused on optimizing MoE training and d ...

Association for Computing Machinery2025

Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure

Johan Auwerx

Chimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show ...

Springer Science and Business Media LLC2025

Let There Be Light: Robust Lensless Imaging Under External Illumination With Deep Learning

Stefan Christian Peters, Martin Vetterli, Eric Bezzam

Lensless cameras relax the design constraints of traditional cameras by shifting image formation from analog optics to digital post-processing. While new camera designs and applications can be enabled, lensless imaging is very sensitive to unwanted interfe ...

IEEE2025

Transmission dynamics of Norovirus GII and Enterovirus in Switzerland during the COVID-19 pandemic (2021-2022) as evidenced in wastewater

Tamar Kohn, Timothy R. Julian, Htet Kyi Wynn, Shotaro Torii, Charles Zeng Gan

Noroviruses and enteroviruses are major causes of endemic gastrointestinal disease associated with substantial disease burden. However, viral gastroenteritis is often diagnosed based on symptoms, with etiology infrequently tested or reported, so little inf ...

Elsevier BV2025

Epistatic interaction between ERAP2 and HLA modulates HIV-1 adaptation and disease outcome in an Australian population

Jacques Fellay

A strong genetic predictor of outcome following untreated HIV-1 infection is the carriage of specific alleles of human leukocyte antigens (HLAs) that present viral epitopes to T cells. Residual variation in outcome measures may be attributed, in part, to v ...

2024

Towards Practical Homomorphic Aggregation in Byzantine-Resilient Distributed Learning

Rachid Guerraoui, John Stephan

The growing availability of distributed data has led to the increased use of machine learning (ML) algorithms in distributed topologies, where multiple nodes collaborate to train models under the coordination of a central server. However, distributed learn ...

Association for Computing Machinery, Inc2024

Automatic simulation of electrochemical sensors by machine learning for drugs quantification

Sandro Carrara, Francesca Rodino, Lin Du

Multiple drug concentrations concurrent detection and quantification based on electrochemical sensors are of great importance for therapeutic drug monitoring (TDM) and the development of personalized therapy. Cyclic voltammogram (CV) results obtained by el ...

Pergamon-Elsevier Science Ltd2024

In-Silico Trained AI for Enhanced T2Spectrum Imaging and Myelin Water Fraction Mapping in Preclinical 7T MRI

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Thomas Yu

This study introduces a Machine Learning (ML) approach for estimating the T2 spectrum and myelin water fraction (MWF) using multi-echo T2 (MET2) data from preclinical 7T Magnetic Resonance Imaging (MRI) scanners. ML methods have shown promise in MWF estima ...

IEEE Computer Society2024

Backpropagation-free Training of Analog AI Accelerators

Romain Christophe Rémy Fleury, Ali Momeni, Matthieu Francis Malléjac

Deep learning has achieved remarkable success in diverse fields in recent years. However, this growth presents significant challenges, particularly in terms of energy consumption during both training and inference phases. While there have been efforts to i ...

Institute of Electrical and Electronics Engineers Inc.2024

Optimal Inference in Contextual Stochastic Block Models

Lenka Zdeborová, Odilon Marie Cyprien Duranthon

The contextual stochastic block model (CSBM) was proposed for unsupervised community detection on attributed graphs where both the graph and the high-dimensional node information correlate with node labels. In the context of machine learning on graphs, the ...

Journal of Machine Learning Research Inc.2024

Neurobiological and metabolic basis of motivation and effort-based decision-making - A human 1H-MRS, fMRI and machine learning study

Arthur Barakat

Motivation is a multifaceted phenomenon that we explore within the framework of decision-making. Through this cognitive process, actions are directed towards specific goals by performing a trade-off between the cost and benefit of an action. The dorsomedia ...

EPFL2024

Surface functionalization strategies for optimal DNA conjugation on sensing surfaces for virus detection

Perrine Agnes Edith Robin

The COVID-19 pandemic has highlighted the need for new biodetection methods that would enable mass population screening, and help controlling the spread of viral diseases. Such technologies could benefit the prevention of many other infectious diseases. Fo ...

EPFL2024

Multi-Channel Mosra: Mean Opinion Score and Room Acoustics Estimation Using Simulated Data and A Teacher Model

Jozef Marus Coldenhoff

Previous methods for predicting room acoustic parameters and speech quality metrics have focused on the single-channel case, where room acoustics and Mean Opinion Score (MOS) are predicted for a single recording device. However, quality-based device select ...

IEEE2024

Cell density quantification of high resolution Nissl images of the juvenile rat brain

Csaba Zsolnai, Henry Markram, Daniel Keller, Olivier Burri, Rodrigo de Campos Perin, Ying Shi, Julie Meystre, João Luís Prado Vieira, Jean Nicolas Jacquemier

Copyright © 2024 Meystre, Jacquemier, Burri, Zsolnai, Frank, Vieira, Shi, Perin, Keller and Markram.Nissl histology underpins our understanding of brain anatomy and architecture. Despite its importance, no high-resolution datasets are currently available i ...

2024

LegalWriter: An Intelligent Writing Support System for Structured and Persuasive Legal Case Writing for Novice Law Students

Seyed Parsa Neshaei

Novice students in law courses or students who encounter legal education face the challenge of acquiring specialized and highly concept-oriented knowledge. Structured and persuasive writing combined with the necessary domain knowledge is challenging for ma ...

Association for Computing Machinery2024

Content-Based Objective Evaluation of Artificially Generated Sign Language Videos

Neha Tarigopula

Sign language is vital for communication within the deaf and hard-of-hearing community. Avatar-based methods and deep learning techniques like Generative Adversarial Networks have shown promise in generating sign language video content. One of the challeng ...

IEEE2024