The effect of bisphosphonates and titanium particles on osteoblasts: an in vitro study

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Bone marrow adipocytes (BMAds) constitute the most abundant stromal component of adult human bone marrow. Two subtypes of BMAds have been described, the more labile regulated adipocytes (rBMAds) and the more stable constitutive adipocytes (cBMAds), which d ...

The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. We analyzed computed tomography (CT) scans of 441 shoulders ...

beta-Tricalcium Phosphate (beta-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include beta-calcium pyrophosphate (beta-CPP) and hydroxyapatite (HA). Currently, the ef ...

Cells are powerful carriers that can help to improve the delivery of nanomedicines. One approach to use cells as carriers is to immobilize the nanoparticulate cargo on the cell surface. While a plethora of chemical conjugation strategies are available to b ...

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...

We designed and engineered a dye production cassette encoding a heterologous pathway, including human tyrosine hydroxylase and Amanita muscaria 4,5-DOPA dioxygenase, for the biosynthesis of the betaxanthin family of plant and fungal pigments in mammalian c ...

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...

Nowadays, cancer is one of the leading causes of death in developed countries. The actual medical tools to detect cancer at early stage suffer to their low sensitivity. The design of multimodal nanodevices for in vivo imaging offers the perspective of canc ...

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materia ...

Background The edible fruit Annona cherimola has previously shown many nutritional and medicinal properties. The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf extract (AELE) on Acute Myeloid Le ...

Although ferrocene derivatives have attracted considerable attention as possible anticancer agents, the medicinal potential of diiron complexes has remained largely unexplored. Herein, we describe the straightforward multigram-scale synthesis and the antip ...

The potential of human fetal bone cells for successful bone regeneration has been shown in vivo. In particular, it has been demonstrated that the seeding of these cells in porous poly-(L-lactic acid)/ ß-tricalcium phosphate scaffolds improved the bone form ...

Patellar fracture and anterior knee pain remain major complications after Total Knee Arthroplasty (TKA). Patient-specific finite element (FE) models should help improve understanding of these complications through estimation of joint and bone mechanics. Ho ...

Hypothesis: We hypothesized that biomechanical parameters typically associated with glenoid implant failure after anatomic total shoulder arthroplasty (aTSA) would be correlated with preoperative glenoid bone quality. Methods: We developed an objective aut ...

Rotator cuff tear is one of the most common types of shoulder injuries, often resulting in pain and physical debilitation. Allogeneic tendon-derived decellularized matrices do not have appropriate pore size and porosity to facilitate cell infiltration, whi ...

Micromotion-induced interstitial fluid flow at the bone-implant interface has been proposed to play an important role in aseptic loosening of cementless implants. High fluid velocities are thought to promote aseptic loosening through activation of osteocla ...

The effect of bisphosphonates and titanium particles on osteoblasts: an in vitro study

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Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes

Age- and sex-specific normative values of bone mineral density in the adult glenoid

Effect of minor amounts of beta-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of beta-tricalcium phosphate cylinders

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Overcorrected Implants for Total Shoulder Arthroplasty

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

Genetically encoded betaxanthin-based small-molecular fluorescent reporter for mammalian cells

Sub-trabecular strain evolution in human trabecular bone

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Functionalization of second harmonic generation nanoparticles for theranostic applications

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

Anticancer Potential of Diiron Vinyliminium Complexes

Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?

Importance of trabecular anisotropy in finite element predictions of patellar strain after Total Knee Arthroplasty

Cement stress predictions after anatomic total shoulder arthroplasty are correlated with preoperative glenoid bone quality

Alignment of collagen fiber in knitted silk scaffold for functional massive rotator cuff repair

Micromotion-induced peri-prosthetic fluid flow around a cementless femoral stem