Polymer microfluidic chips for electrochemical and biochemical analyses

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The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at le ...

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

Continuous development of thin film deposition technologies is essential for the fabrication of films that meet the specific requirements of their target applications and working conditions. Therefore, it is necessary to increase the number of accessible a ...

Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfac ...

We present the concept and detailed design of a Smart Slit Assembly for next generation spectrometers, and we experimentally demonstrate operation of an individual 221 mu m x 111 mu m smart slit channel employing a MEMS actuated shutter to continuously mod ...

Dielectric breakdown etching is a well-known method of making nanopores on thin (similar to 50 nm) dielectric membranes. However, voltage driven translocation of biomolecules through such nanopores becomes extremely fast. For improved detection, for instan ...

We present the concept and design, and we report on the experimental performance of a broadband Variable Optical Attenuator (VOA) for integration with large-core rectangular multimode waveguides. Operation of an individual 221 mu m x 111 mu m optical waveg ...

We present here, for the first time, a fabrication technique that allows manufacturing scallop free, non-tapered, high aspect ratio in through-silicon vias (TSVs) on silicon wafers. TSVs are among major technology players in modern high-volume manufacturin ...

Alpha-synuclein oligomerization is one of the early events on the pathway to Lewy body formation. Therefore, interfering with this process holds tremendous potential for developing therapies that block alpha-Syn pathology formation and toxicity. The develo ...

The discovery of room-temperature single photon emission from color centers in diamond has in recent years boosted research interest in this renowned material in photonics and quantum community and beyond. Following understanding some basic principles of h ...

Drug discovery is a complex, multistep process, in which many challenges need to be overcome at each stage, from the discovery of a biomolecular target to the ensuring of the efficacy and safety of a compound in humans. Today's analytical methods allow ten ...

Silicon nanowire-based sensors find many applications in micro- and nano-electromechanical systems, thanks to their unique characteristics of flexibility and strength that emerge at the nanoscale. This work is the first study of this class of micro- and na ...

G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...

Refractive microlenses and microlens arrays are key components for many applications such as optical data communication, laser and medical devices, or cameras. In particular, refractive micro-optics enables the miniaturization of high-tech systems but also ...

The k(off) values of ligands unbinding to proteins are key parameters for drug discovery. Their predictions based on molecular simulation may under- or overestimate experiment in a system- and/or technique-dependent way. Here we use an established method-i ...

Despite significant advances in the treatment of cardiovascular diseases, antiplatelet therapies are still associated with a high risk of hemorrhage. In order to develop new drugs, methods to measure platelet function must be adapted for the high-throughpu ...

Selected set of samples from JET ITER-Like Wall (JET-ILW) divertor tiles exposed both in 2013-2014 and 2011-2014 has been analysed using Thermal Desorption Spectrometry (TDS). The deuterium (D) amounts obtained with TDS were compared with Ion Beam Analysis ...

Many central biological events rely on protein-ligand interactions. The identification and characterization of protein-binding sites for ligands are crucial for the understanding of functions of both endogenous ligands and synthetic drug molecules. G prote ...

Well-validated chemical probes enable testing of biological hypotheses, investigation of target tractability and translatability to the clinical phase. Consequently, these important tool compounds play a key role in the drug discovery process. Moreover, th ...

Numerous analytical techniques for life sciences have been at the basis of the improvement of medical diagnostics and treatments. Current challenges in bioanalytics are related to the conception of methods enabling large amount of information to be extract ...

Polymer microfluidic chips for electrochemical and biochemical analyses

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Bodily implant microelectrode and bodily implant microelectrode fabrication method

Improved microfluidic transcriptome based screening methods

Plasma-Assisted Hybrid Vapour Deposition Technology for Thin Film Fabrication

Design and Preparation of Sensing Surfaces for Capacitive Biodetection

Smart Slit Assembly Employing Continuously Tunable MEMS Shutter

Optimized electrochemical breakdown etching using temporal voltage variation for formation of nanopores in a silicon membrane

Mems Shutter Based Variable Optical Attenuator Integrated With Large Core Multimode Rectangular Waveguides

The Michelangelo step: removing scalloping and tapering effects in high aspect ratio through silicon vias

Shining Diamond: from Micro- and Nano-Engineering to Quantum Photonics

Miniaturized technologies for high-throughput drug screening enzymatic assays and diagnostics - A review

Real- and Q-space travelling: multi-dimensional distribution maps of crystal-lattice strain (epsilon(044)) and tilt of suspended monolithic silicon nanowire structures

Enhancing the Signaling of GPCRs via Orthosteric Ions

On the assessment of aspheric refractive microlenses

Accuracy of Molecular Simulation-Based Predictions of k(off) Values: A Metadynamics Study

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

Investigation of deuterium trapping and release in the JET ITER-like wall divertor using TDS and TMAP

New Binding Sites, New Opportunities for GPCR Drug Discovery

Design and validation of bioorthogonal probes for cellular disease models

Integration of microfluidics and multimodal optics for translational bioanalytics