Publication

Rapid Synthesis of Defined Eukaryotic Promoter Libraries

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Polynomial Networks (PNs) have demonstrated promising performance on face and image recognition recently. However, robustness of PNs is unclear and thus obtaining certificates becomes imperative for enabling their adoption in real-world applications. Exist ...

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Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

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Our genome is a long sequence of DNA that contains all the information to be able to constitute a living organism like us, similarly to what the letters in a book do to create a story. This sequence, which is a stretch of molecules called nucleotides, is a ...

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Circadian dynamics of RNA localisation in the mammalian liver

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Gene expression in eukaryotes is a complex multi-step process. It starts in the nucleus with transcription, the synthesis of a mRNA copy from a DNA template. While in the nucleus, the RNA transcript is subject to multiple co- and post-transcriptional modif ...

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Author summary Transcription of genes by the RNA polymerase II enzyme initiates at a genomic region termed the core promoter. The core promoter is a regulatory region that may contain diverse short DNA sequence motifs/elements that confer specific properti ...

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Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

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In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is a ...

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