Early Cell Death Detection with Digital Holographic Microscopy

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Current imaging technologies are limited in their capability to simultaneously capture intracellular and extracellular dynamics in a spatially and temporally resolved manner. This study presents a multimodal imaging system that integrates nanoplasmonic sen ...

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A series of Ga(Q(n))(3) coordination compounds have been synthesized, where HQ(n) is 1-phenyl-3-methyl-4-RC(=O)-pyrazolo-5-one. The complexes have been characterized through analytical data, NMR and IR spectroscopy, ESI mass spectrometry, elemental analysi ...

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This manuscript proposes a new dual-mode cell imaging system for studying the relationships between calcium dynamics and the contractility process of cardiomyocytes derived from human-induced pluripotent stem cells. Practically, this dual-mode cell imaging ...

State-of-the-art object detection and segmentation methods for microscopy images rely on supervised machine learning, which requires laborious manual annotation of training data. Here we present a self-supervised method based on time arrow prediction pre-t ...

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Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize cellular heterogeneity(1). However, scRNA-seq requires lysing cells, which impedes further molecular or functional analyses on the same cells. Here, we established Liv ...

Early Cell Death Detection with Digital Holographic Microscopy

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Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single-Cell Secretory and Intracellular Dynamics

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

Live-cell imaging powered by computation

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Modular segmentation, spatial analysis and visualization of volume electron microscopy datasets

Characterization of the gut-bone marrow axis through bile acid signaling

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Simple optical nanomotion method for single-bacterium viability and antibiotic response testing

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities

Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes

Self-supervised Dense Representation Learning for Live-Cell Microscopy with Time Arrow Prediction

Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells

Optical microscopy gets down to angstroms

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Live-seq enables temporal transcriptomic recording of single cells