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Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?

Publications associées (29)

Influence of the shear stress on fine sediment exchanges with the substrate using UVP measurements

Giovanni De Cesare, Romain Maxime Dubuis

The dynamic of fine sediment in rivers is closely related to the interactions between fine particles, the riverbed and the flow conditions. The accumulation of fine sediment in the riverbed reduces vertical water exchanges and can have detrimental effects ...

2023

Study of backward Brillouin scattering in gas-filled anti-resonant fibers

Luc Thévenaz, Li Zhang, Malak Mohamed Hossameldeen Omar Mohamed Galal

Brillouin scattering in gas shows unmatched gain properties in hollow-core optical fibers filled at high pressure. Here, the gain characteristics are studied for two common gases, namely, N2 and CO2, which show distinct features and are compared to expecte ...

2023

On the Post-peak Behaviour of Remoulded and Jointed Clay Samples During Triaxial Compression Tests

Alessio Ferrari

The note presents a selection of the results of a large experimental program conducted with the aim of characterizing the shear strength of Opalinus Clay and Speswhite Kaolin in remoulded and reconstituted conditions, through the execution of unconventiona ...

2023

Nanomechanical Modeling of the Bending Response of Silicon Nanowires

Yusuf Leblebici, Zuhal Tasdemir, Mustafa Yilmaz, Mohammad Nasr Esfahani

Understanding the mechanical behavior of silicon nanowiresis essentialfor the implementation of advanced nanoscale devices. Although bendingtests are predominantly used for this purpose, their findings shouldbe properly interpreted through modeling. Variou ...

AMER CHEMICAL SOC2023

Reduced order modeling of parametrized pulsatile blood flows: Hematocrit percentage and heart rate

Ricardo Reyes Sotomayor

This paper numerically evaluates the accuracy and performance of a stabilized finite element Reduced Order Modelling (ROM) approach that is designed to simulate pulsatile blood flows. The method is able to estimate fluid flow parametric solutions of intere ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

Jacques Fellay, Christian Axel Wandall Thorball

Leukocyte count is associated with coronary artery disease (CAD) events in the general population. Here we show that leukocytes are independently associated with CAD events in people with HIV in Switzerland, after adjusting for traditional and HIVrelated r ...

OXFORD UNIV PRESS INC2023

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Bart Deplancke, Jorieke Weiden, Guido Van Mierlo

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...

AMER CHEMICAL SOC2023

Nanotechnology enabled modulation of T cell immunity for cancer treatment

Xiaomeng Hu

Recent breakthroughs in cancer immunotherapy, exemplified by immune checkpoint blockade and CAR T cell therapy, have achieved remarkable clinical success. However, the majority of cancer patients fail to respond to immunotherapy or suffer from relapse. Nan ...

EPFL2023

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

Min Gao

Cancer immunotherapy has become an attractive strategy among different therapeutic modalities over the past few years and has showed great success in the clinic. However, there are many outstanding challenges hindering the current immunotherapies. In my Ph ...

EPFL2023