Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

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Lipid membranes are complex and dynamic systems which are known to mediate signaling processes between cells and their environment. To do this multiple ion channels and pumps are involved in controlling the in- and out-flux of various ions (K+, Na+, Mg2+, ...

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A Molecular Logic Gate Enables Single-Molecule Imaging and Tracking of Lipids in Intracellular Domains

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Photoactivatable dyes enable single-molecule imaging and tracking in biology. Despite progress in the development of new fluorophores and labeling strategies, many intracellular compartments remain difficult to image beyond the limit of diffraction in livi ...

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Development of chemical biology tools to reveal the function and organization of the silenced chromatin state

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Effector proteins are recruited to chromatin via transient interactions between their reader domains and histone post-translational modification (PTM) patterns. These interactions form signaling pathways that control gene expression or repression and which ...

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Prospects of Observing Ionic Coulomb Blockade in Artificial Ion Confinements

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Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

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Mycobacterium tuberculosis, the etiological agent for the tuberculosis disease, is a bacterial pathogen thought to infect about a quarter of the global human population. It is the first cause of death among infectious diseases, and is most prevalent in low ...

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Mammalian membrane trafficking as seen through the lens of bacterial toxins

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A fundamental question of eukaryotic cell biology is how membrane organelles are organised and interact with each other. Cell biologists address these questions by characterising the structural features of membrane compartments and the mechanisms that coor ...

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Structural mechanism of cGAS inhibition by the nucleosome

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2020

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

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Current approaches to introduce terminal alkynes for bioorthogonal reactions into biomolecules still present limitations in terms of either reactivity, selectivity, or adduct stability. We present a method for the ethynylation of cysteine residues based on ...

Wiley-VCH Verlag GmbH2020