Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

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Cross-validation is commonly used to select the recommendation algorithms that will generalize best on yet unknown data. Yet, in many situations the available dataset used for cross-validation is scarce and the selected algorithm might not be the best suit ...

A capillary jet falling under the effect of gravity continuously stretches while thinning downstream. We report here the effect of external periodic forcing on such a spatially varying jet in the jetting regime. Surprisingly, the optimal forcing frequency ...

There is an increasing interest in cationic polymers as important constituents of non-viral gene delivery vectors. In the present study, we developed a versatile synthetic route for the production of covalent polymeric conjugates consisting of water-solubl ...

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

Maintaining a metabolic steady state is essential for an organism's fitness and survival when confronted with environmental stress, and metabolic imbalance can be reversed by exposing the organism to fasting. Here, we attempted to apply this physiological ...

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

Understanding macroevolutionary patterns is central to evolutionary biology. This involves the process of divergence within a species, which starts at the microevolutionary level, for instance, when two sub populations evolve towards different phenotypic o ...

For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showin ...

We designed and engineered a dye production cassette encoding a heterologous pathway, including human tyrosine hydroxylase and Amanita muscaria 4,5-DOPA dioxygenase, for the biosynthesis of the betaxanthin family of plant and fungal pigments in mammalian c ...

Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

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The Imitation Game: Algorithm Selection by Exploiting Black-Box Recommenders

Frequency selection in a gravitationally stretched capillary jet in the jetting regime

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Transient vitamin B5 starving improves mammalian cell homeostasis and protein production

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

Linking micro and macroevolution in the presence of migration

Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection-A Simulation Study

Genetically encoded betaxanthin-based small-molecular fluorescent reporter for mammalian cells