Publications associées à Rational cytokine and receptor engineering for enhanced safety and efficacy of cancer immunotherapy

Publications associées (9)

Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors?

In the last two decades, novel and promising cell-based therapies have populated the treatment landscape for haematological tumors. However, commonly exploited T and NK cell-based therapies show limited applicability to solid tumors. This is mainly given b ...

2025

A redox-responsive prodrug for tumor-targeted glutamine restriction

Xile Hu, Li Tang, Daniel Ortiz Trujillo, Bing Feng, Céline Jasmin Prange, Christine Göpfert, Nadia Yasmina Ben Sayed

Modulating the metabolism of cancer cells, immune cells, or both is a promising strategy to potentiate cancer immunotherapy in the nutrient-competitive tumor microenvironment. Glutamine has emerged as an ideal target as cancer cells highly rely on glutamin ...

Elsevier2024

A nuclear jamming transition in vertebrate organogenesis

Sangwoo Kim

Jamming of cell collectives and associated rigidity transitions have been shown to play a key role in tissue dynamics, structure and morphogenesis. Cellular jamming is controlled by cellular density and the mechanics of cell-cell contacts. However, the con ...

NATURE PORTFOLIO2024

A humoral stress response protects Drosophila tissues from antimicrobial peptides

Matteo Dal Peraro, Bruno Lemaitre, Chan Cao, Samuel Rommelaere, Jean Philippe Boquete, Verena Rukes, Fernando Augusto Teixeira Pinto Meireles, Alexia Laurie Carboni

An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host ...

Elsevier BV2024

Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro

Hilal Lashuel, Yllza Jasiqi, Lixin Yang

TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberrant misfolding or ...

Amer Chemical Soc2023

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

Linlin Cao

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...

EPFL2023

Nano-Motion Analysis for Rapid and Label Free Assessing of Cancer Cell Sensitivity to Chemotherapeutics

Sandor Kasas, María Inés Villalba, Petar Stupar

Background and Objectives: Optimization of chemotherapy is crucial for cancer patients. Timely and costly efficient treatments are emerging due to the increasing incidence of cancer worldwide. Here, we present a methodology of nano-motion analysis that cou ...

2021

MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis

Jelena Zaric

MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, beta 3-integrin, talin 1, tensin 3 and alpha-4-acti ...

2021

Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase

Matteo Dal Peraro, Alessio Prunotto

Endolysins are bacteriophage-encoded peptidoglycan hydrolases targeting the cell wall of host bacteria via their cell wall-binding domains (CBDs). The molecular basis for selective recognition of surface carbohydrate ligands by CBDs remains elusive. Here, ...

2021