Publications associées à Unsymmetrical Trifluoromethyl Methoxyphenyl beta-Diketones: Effect of the Position of Methoxy Group and Coordination at Cu(II) on Biological Activity

Publications associées (13)

Peptide‐Carbazolyl Cyanobenzene Conjugates: Enabling Biomolecule Functionalization via Photoredox and Energy Transfer Catalysis

Jérôme Waser, Beat Fierz, Anne-Sophie Chauvin, Xingyu Liu, Wei Cai

Since their discovery in 2012, carbazolyl (iso)phthalonitrile derivatives (Cz(I)PN) have found significant applications as photocatalysts in organic chemistry. Herein, we introduce two efficient methods for incorporating carbazolyl cyanobenzenes into vario ...

Wiley2025

Natural and simulated weathering of polystyrene: A molecular view of the polymeric interface

Christian Ludwig, Florian Frédéric Vincent Breider, Michel Rossi, Tobias Borgmeyer, Lu Zhou

This work presents the changing abundance of surface functional groups (SFGs) on polystyrene (PS) upon weathering within one or a few molecular monolayers from a molecular point of view. PS particles were aged by exposing it to a gas flow of typically (5 % ...

Elsevier BV2024

A score and nine years of irbesartan

Farzaneh Fadaei Tirani

Irbesartan is a non-peptide antagonist of the angiotensin-II-AT1 receptor and is used for the treatment of hypertension. Here, the history, achievements and open questions related to irbesartan are examined. Tautomery of the tetrazole moiety leads to two d ...

2024

Engineering nanomaterial surfaces for biomedical applications: antiviral surface coatings, antiviral nanoparticles and lipid-based biopharmaceutical drug systems

Heyun Wang

Nanomaterial surfaces can be engineered by chemical modifications for the modulation of various surface properties including surface charges, hydrophobicity and chemical reactivity. These properties modulate in turn the interactions between the nanomateria ...

EPFL2024

Unlocking Multi-scenario Sensing Capabilities in the Mid-ir Using Polycrystalline Silicon Metasurfaces

Simone Iadanza

The design and operational principles governing all-dielectric metasurfaces, operating in the 4 similar to 8 mu m mid-infrared band and customizable for gas and liquid sensing, are presented. A comparative analysis of silicon meta-atoms on CaF2 or Si3N4 su ...

IEEE2024

Harnessing data science to improve molecular structure elucidation from tandem mass spectrometry

Fernando Perez Cruz, Guillaume Romain Obozinski, Marco Volpi

Compound structural identification for non-targeted screening of organic molecules in complex mixtures is commonly carried out using liquid chromatography coupled to tandem mass spectrometry (UHPLC-HRMS/MS and related techniques). Instrumental developments ...

2023

Direct Observation of the Phase Transition in C60 Fullerene

Chengcheng Yan

In the third study, the order-disorder phase transition of single-crystal C60 is studied using time-resolved electron microscopy. Solid C60 undergoes a first-order phase transition upon heating to 260 K. This is a structural transition from the low-tempera ...

EPFL Infoscience2023

Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42

Horst Arthur Vogel

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific inhibitor of ClC- ...

Nature Portfolio2023

Unraveling the Oxidation of a Graphitic Lattice: Structure Determination of Oxygen Clusters

Nicola Marzari, Kumar Varoon Agrawal, Shiqi Huang, Shaoxian Li

Unraveling the oxidation of graphitic lattice is of great interest for atomic-scale lattice manipulation. Herein, we build epoxy cluster, atom by atom, using Van der Waals' density-functional theory aided by Clar's aromatic it-sextet rule. We predict the f ...

Amer Physical Soc2023

Water inhibition and role of palladium adatoms on Pd/Al2O3 catalysts during methane oxidation

Maneka Claire Roger

Supported palladium catalysts are the most active ones toward the complete oxidation of methane. However, the presence of relevant amounts of water hinders the catalytic activity and long-term stability, due to competition between methane and water for the ...

2022

Molecular Stabilization of Sub-Nanometer Cu Clusters for Selective CO2 Electromethanation

Jun Li

Electrochemical CO2 methanation powered by renewable electricity provides a promising approach to utilizing CO2 in the form of a high-energy-density, clean fuel. Cu nanoclusters have been predicted by theoretical calculations to improve methane selectivity ...

WILEY-V C H VERLAG GMBH2022

Facile synthesis of heterobimetallic [Fe II (?-diphosphine)Ru II ] and homobimetallic [Fe II (?-diphosphine)Fe II ] complexes and their in vitro cytotoxic activity on cisplatin-resistant cancer cells

Paul Joseph Dyson, Mouna Hadiji

2020

Spectroscopy and Photoexcitation Dynamics of Ions in Helium Nanodroplets

Xiaohang Zhang

EPFL2013