Systems Biology of 3D Stem Cell-Niche Interactions

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Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

Halima Hannah Emilie Schede

Cellular function and behavior are governed not only by molecular composition but also by a cell's native environmental context. By leveraging in-depth molecular quantification and high-resolution imaging methods to study microenvironmental composition and ...

EPFL2025

Design-Oriented Analytical Model for Nanowire Biosensors Including Dynamic Aspects

Jean-Michel Sallese, Farzan Jazaeri, Ashkhen Yesayan

Nanowire field-effect transistor (NW FET) biosensors are known to be highly sensitive devices that can detect extremely low concentrations of biomolecules. In this article, we present an analytical model alongside with numerical simulations to calculate th ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2025

Impact of phylogeny on inference from protein sequences: from models to natural data

Nicola Dietler

Proteins are macromolecules considered as the building blocks of cells because they are at the heart of almost every cellular task, ranging from chemical to mechanical processes. For instance, proteins play a role as enzymes for digestion, transporters of ...

EPFL2024

Bioengineering in vitro models of embryonic development

Matthias Lütolf

Stem cell-based in vitro models of embryonic development have been established over the last decade. Such model systems recapitulate aspects of gametogenesis, early embryonic development, or organogenesis. They enable experimental approaches that have not ...

2021