Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule

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With the increase in life expectancy and the rapid evolution of daily life technologies, older adults must constantly learn new skills to adapt to society. Sleep reinforces skills acquired during the day and is associated with the occurrence of specific os ...

The preclinical phase of Alzheimer’s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and t ...

The Emo-FilM dataset stands for Emotion research using Films and fMRI in healthy participants. This dataset includes emotion annotations by 44 raters for 14 short films with a combined duration of over 2 1/2 hours and recordings of respiration, heart rate, ...

This study aims to determine whether 1) individuals with treatment-resistant schizophrenia display early cognitive impairment compared to treatment-responders and healthy controls and 2) N-methyl-D-aspartate-receptor hypofunction is an underlying mechanism ...

Music is ubiquitous, both in its instrumental and vocal forms. While speech perception at birth has been at the core of an extensive corpus of research, the origins of the ability to discriminate instrumental or vocal melodies is still not well investigate ...

Most patients with Parkinson's disease (PD) are not only affected by motor symptoms (e.g., tremor, rigidity, bradykinesia), but also experience hallucinations. Importantly, hallucinations are a risk factor for a more rapid cognitive decline, dementia, and ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct f ...

Background: Cognitive behavioral therapy (CBT) is the current standard treatment for chronic severe tinnitus; however, preliminary evidence suggests that real-time functional MRI (fMRI) neurofeedback therapy may be more effective. Purpose: To compare the e ...

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Aim: Adolescents born very preterm (VPT;

A frequency scaling governor is critical for the performance management of cloud servers, as it enhances energy efficiency and helps to control operational temperatures, thereby ensuring system reliability. However, our in-depth analysis of the application ...

Fluorescence lifetime imaging (FLI) has been receiving increased attention in recent years as a powerful diagnostic technique in biological and medical research. However, existing FLI systems often suffer from a tradeoff between processing speed, accuracy, ...

Electric vehicles (EVs) are becoming more popular due to environmental consciousness. The limited availability of charging stations (CSs), compared to the number of EVs on the road, has led to increased range anxiety and a higher frequency of CS queries du ...

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

Grid cells in the entorhinal cortex (EC) encode an individual’s location in space, integrating both environmental and multisensory bodily cues. Notably, body-derived signals are also primary signals for the sense of self. While studies have demonstrated th ...

Cognitive decline and hallucinations are common and debilitating non-motor symptoms, usually occurring during later phases of Parkinson’s disease (PD). Minor hallucinations (MH) appear early in the disease course and have been suggested to predict cognitiv ...

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

This short essay illustrates the role of the business archive in the transmission and maintenance of contemporary industrial culture, with a focus on the company town of Dalmine. In the context of Dalmine, the business archive managed by the Fondazione Dal ...

Background: A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack of awareness of memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic netw ...

Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule

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Impact of spindle-inspired transcranial alternating current stimulation during a nap on sleep-dependent motor memory consolidation in healthy older adults

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Emo-film: a Multimodal Dataset for Affective Neuroscience Using Naturalistic Stimuli

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

Newborn's neural representation of instrumental and vocal music as revealed by fMRI: A dynamic effective brain connectivity study

Sensorimotor and social mechanisms of hallucinations in healthy participants and patients with Parkinson's Disease

White adipose tissue distribution and amount are associated with increased white matter connectivity

The interplay between white adipose tissue, adipokines, and structural gray matter changes

Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Impact of a mindfulness-based intervention on neurobehavioral functioning and its association with large-scale brain networks in preterm young adolescents

Is the powersave governor really saving power?

Coupling a recurrent neural network to SPAD TCSPC systems for real-time fluorescence lifetime imaging

A Privacy-Preserving Querying Mechanism with High Utility for Electric Vehicles

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Changes in spatial self-consciousness elicit grid cell–like representation in the entorhinal cortex

Theta oscillations and minor hallucinations in Parkinson’s disease reveal decrease in frontal lobe functions and later cognitive decline

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

When the industry built the city: business archives, memory and community in a contemporary company town

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection