Publications associées à Standardized Production of Anti-Desmoglein 3 Antibody AK23 for Translational Pemphigus Vulgaris Research

Publications associées (8)

Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadly type of cancer, with an extremely low five-year overall survival rate. To date, current treatment options primarily involve various chemotherapies, which often prove ineffecti ...

Springer Science and Business Media LLC2025

Molecular characterization of an adhesion GPCR signal transduction using Graph-neural networks

Matthieu François Marfoglia

Key cellular functions depend on the transduction of extracellular mechanical signals by specialized membrane receptors, including adhesion G-protein coupled receptors (aGPCRs). While recent structural studies support aGPCR activation through shedding of t ...

EPFL2025

Rational design of small-molecule responsive protein switches

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Sailan Shui, Stephen Michael Buckley

Small-molecule responsive protein switches are powerful tools for controlling cellular processes. These switches are designed to respond rapidly and specifically to their inducer. They have been used in numerous applications, including the regulation of ge ...

2023

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Johan Auwerx, Olaia Maria Naveiras Torres-Quiroga, Frédérica Schyrr, Charles Christopher Bataclan

Aging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During agin ...

SPRINGERNATURE2023

Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Cem Tekin, Kaltrina Paloja, Jorieke Weiden

WILEY2021

The spatial organization of cGAS-TREX1 interactions

Andrea Ablasser, Paula Juricic Dzankic

Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021) and Zho ...

Cell Press - Elsevier2021

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui

The optimization of therapeutic antibodies is time-intensive and resource-demanding, largely because of the low-throughput screening of full-length antibodies (approximately 1 x 10(3) variants) expressed in mammalian cells, which typically results in few o ...

NATURE RESEARCH2021

Mechanical Immunoengineering of T-cells for Therapeutic Applications

Li Tang, Armand Kurum, Kewen Lei

T cells, a key component in adaptive immunity, are central to many immunotherapeutic modalities aimed at treating various diseases including cancer, infectious diseases, and autoimmune disorders. The past decade has witnessed tremendous progress in immunot ...

American Chemical Society2020