Reply to Comment by Jennings et al. on "Investigating Earth's Formation History Through Copper and Sulfur Metal-Silicate Partitioning During Core-Mantle Differentiation"

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Blocked radiative heat transport in the hot pyrolitic lower mantle

James Badro, Farhang Nabiei, Hélène Marie Piet

The heat flux across the core-mantle boundary (Q(CMB)) is the key parameter to understand the Earth's thermal history and evolution. Mineralogical constraints of the Q(CMB) require deciphering contributions of the lattice and radiative components to the th ...

ELSEVIER2020

Ultrafast X-ray Spectroscopy of Heme Proteins

Dominik Kinschel

With the advent of X-ray free-electron lasers (XFELs) time-resolved X-ray spectroscopic techniques have advanced to the femtosecond regime. These are element selective techniques which offer unique insight into the electronic and chemical environment and d ...

EPFL2020

Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation

Edoardo Charbon, Claudio Bruschini, Ming-Lo Wu, Kazuhiro Morimoto

Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a rela ...

NATURE RESEARCH2020

Metal-organic framework derived copper catalysts for CO2 to ethylene conversion

Jun Li

The electrochemical reduction of CO2 to ethylene provides a carbon-neutral avenue for the conversion of CO2 to value-added fuels and feedstocks, so contributing to the storage of intermittent renewable electricity. The exploration of efficient electrocatal ...

Royal Society of Chemistry2020

Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get

Hilal Lashuel, Nathan Alain Denis Riguet

Bimolecular fluorescence complementation (BiFC) was introduced a decade ago as a method to monitor alpha-synuclein (alpha-syn) oligomerization in intact cells. Since then, several alpha-syn BiFC cellular assays and animal models have been developed based o ...

Wiley-Blackwell2021

Photoactivatable Silicon Rhodamines for Super-Resolution Microscopy

Michelle Susanne Frei

Fluorescence microscopy is the method of choice to monitor dynamic processes in living cells due to its non-invasive nature. A variety of different fluorophores and labeling systems are currently used to selectively visualise structures or biomolecules of ...

EPFL2020

Combined synchrotron x-ray diffraction and NV diamond magnetic microscopy measurements at high pressure

Margarita Lesik Gaussens, Mayeul Sylvain Chipaux, Charles Michel Henri Pépin

We report the possibility to simultaneously perform wide-field nitrogen-vacancy (NV) diamond magnetic microscopy and synchrotron x-ray diffraction measurements at high pressure. NV color centers are created on the culet of a diamond anvil which is integrat ...

2020

Temporal resolution doubling in fluorescence light-sheet microscopy via a hue-encoded shutter and regularization

Michael Stefan Daniel Liebling, Christian Jaques

Studying dynamic biological processes, such as heart development and function in zebrafish embryos, often relies on multi-channel fluorescence labeling to distinguish multiple anatomical features, yet also demands high frame rates to capture rapid cell mot ...

2020

Chemistry and Analysis of Nanoparticle-Modified Living Cells

Tanja Thomsen

Conventional therapeutics are often limited by their targeting ability, resulting in harmful and potential fatal side-effects for the patients. Recently, new strategies have been developed to improve target specificity of drugs in order to generate more ef ...

EPFL2020

Effects of composition and pressure on electronic states of iron in bridgmanite

Philippe Gillet, Arnaud Magrez, Susannah McGregor Dorfman

Electronic states of iron in the lower mantle's dominant mineral, (Mg,Fe,Al)(Fe,Al,Si)O-3 bridgmanite, control physical properties of the mantle including density, elasticity, and electrical and thermal conductivity. However, the determination of electroni ...

MINERALOGICAL SOC AMER2020