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In this work, we highlight an issue that may reduce the accuracy of many local nonlinear gyrokinetic simulations – turbulent self-interaction through the parallel boundary condition. Given a sufficiently long parallel correlation length, individual turbulent eddies can span the full domain and ‘bite their own tails’, thereby altering their statistical properties. Such self-interaction is only modelled accurately when the simulation domain corresponds to a full flux surface, otherwise it is artificially strong. For Cyclone Base Case parameters and typical domain sizes, we find that this mechanism modifies the heat flux by approximately 40 % and it can be even more important. The effect is largest when using kinetic electrons, low magnetic shear and strong turbulence drive (i.e. steep background gradients). It is found that parallel self-interaction can be eliminated by increasing the parallel length and/or the binormal width of the simulation domain until convergence is achieved.