Publication

Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation

Publications associées (29)

Towards an in vitro cardiac model: 3D environment, co-culture, alignment, and mechanical stimulation impact on cell behavior

Our aim is to develop a 3D model unit of cardiac muscle: an in-vitro analog of the trabeculae carneae found in vivo. As a base hydrogel matrix for cardiomyocyte culture in 3D, we develop a blend of decellularized extracellular matrix (dECM) and fibrin. Thi ...

EPFL2021

Stiff, Strong, Tough, and Highly Stretchable Hydrogels Based on Dual Stimuli-Responsive Semicrystalline Poly(urethane–urea) Copolymers

Pascal Alexander Schouwink, Nicolas Candau, Adrien Julien Demongeot, Oguzhan Oguz

There has been a considerable interest in developing stiff, strong, tough, and highly stretchable hydrogels in various fields of science and technology including biomedical and sensing applications. However, simultaneous optimization of stiffness, strength ...

2021

Polymer or polycondensate based on peptide, linker and optionally other monomers and method for preparing the same

Li Tang, Lixia Wei, Yu Zhao

The present invention concerns a method for producing polymers suitable as carrier-free delivery system of bioactive molecules, in particular bioactive peptides. The method comprises the polycondensation of one or more different monomers, including monomer ...

2021

Mechanical Activation of Chemical Bonds at Polymer Interfaces

Julian Nicolas Bleich

Polymer brushes are a specific class of polymer thin films in which each chain is tethered to the underlying substrate via one chain end. In sufficiently densely grafted assemblies, the individual polymer chains are forced into an extended chain conformati ...

EPFL2021

Control and Characterization of the Compactness of Single-Chain Nanoparticles

Francesco Stellacci, Luciano Andres Abriata, Lixia Wei, Suiyang Liao

Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to folded proteins; yet proteins have clear energy landscapes that determine precisely folded structures, while single-chain polymer nanoparticles (SCNPs) have more undef ...

American Chemical Society2021

A Strategy to Conjugate Bioactive Fragments to Cytotoxic Diiron Bis(cyclopentadienyl) Complexes

Paul Joseph Dyson, Mouna Hadiji, Silvia Schoch, Sarah Alexandra Pais Pereira

A series of bioactive molecules were synthesized from the condensation of aspirin or chlorambucil with terminal alkynes bearing alcohol or amine substituents. Insertion of the resulting alkynes into the iron-carbyne bond of readily accessible diiron bis(cy ...

AMER CHEMICAL SOC2021

Mechanical reinforcement and memory effect of strain-induced soft segment crystals in thermoplastic polyurethane-urea elastomers

Nicolas Candau, Adrien Julien Demongeot, Oguzhan Oguz

An amorphous poly(urethane-urea) copolymer composed of 70 wt% poly(ethylene oxide) (PEO) soft segments (SS) (Mw = 2000 g mol−1) and 30 wt% cycloaliphatic hard segments (HS) was subjected to in-situ X-Rays during tensile deformation. Mechanical hardening at ...

2021

Synthesis of branching morphologies

Henry Markram, Lida Kanari

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for generating model neurons. In one aspect, a method includes receiving a plurality of descriptions of branches of dendrites of one or more neurons and gener ...

2021

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Oriane Poupart

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

EPFL2021