Publication

A 130nm CMOS Single Photon Avalanche Diode

Publications associées (32)

Quantitative Microstructural Imaging for Clinical Use

Today, Magnetic Resonance Imaging (MRI) is a well-established medical imaging modality thanks to its excellent soft tissue contrast. Conventional MR image contrasts can be weighted towards one or more physical properties that discriminate different tissues ...

EPFL2021

Contrast-Enhanced Ultrasound Quantification: From Kinetic Modeling To Machine Learning

Marcel Arditi

Ultrasound contrast agents (UCAs) have opened up immense diagnostic possibilities by combined use of indicator dilution principles and dynamic contrast-enhanced ultrasound (DCE-US) imaging. UCAs are microbubbles encapsulated in a biocompatible shell. With ...

2020

Subcellular Chemical Imaging: New Avenues in Cell Biology

Melissa Kathleen Passarelli

To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical i ...

ELSEVIER SCIENCE LONDON2020

Roadmap toward the 10 ps time-of-flight PET challenge

Mathieu Benoit, Edoardo Charbon, Christian Morel, Joao Varela

Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with an unprecedented sensitivity at the picomolar level, especially for cancer diagnosis and the monitoring of its response to therapy. Mor ...

IOP PUBLISHING LTD2020

Image reconstruction for novel time domain near infrared optical tomography: towards clinical applications

Edoardo Charbon, Scott Anthony Lindner, Jingjing Jiang, Chunmin Zhang, Martin Wolf

Near infrared optical tomography (NIROT) is an emerging modality that enables imaging the oxygenation of tissue, which is a biomarker of tremendous clinical relevance. Measuring in reflectance is usually required when NIROT is applied in clinical scenarios ...

2020

Single-photon avalanche diode imagers in biophotonics: review and outlook

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Ivan Michel Antolovic, Harald Arjan Robert Homulle

Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very ...

2019

Optical projection tomography for whole organ imaging

David Nguyen

In the past twenty years, far-reaching studies of molecular and cellular processes have reached a milestone in their maturation, and the knowledge from these studies was ready to apply at higher organizational levels. At that time, rodent models were long ...

EPFL2019

Recent advances with optical upconverters made from all-organic and hybrid materials

Roland Hany, Karen Verena Strassel

The growing interest in near-infrared (NIR) imaging is explained by the increasing number of applications in this spectral range, which includes process monitoring and medical imaging. NIR-to-visible optical upconverters made by integrating a NIR photosens ...

2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Novel Molecular Probes for Non-invasive Optical Imaging of Fatty Acid and Triglyceride Uptake in Living Animals

Grigory Karateev

Molecular imaging allows noninvasive visualization of biological processes in their native environment within living systems. It can give a better understanding of fundamental biology, help in identifying disease mechanisms and visualizing pathological tis ...

EPFL2019

Photoluminescence Lifetime Sensor Pixels using SPADs and Silicon LEDs in Commercial CMOS

Edoardo Charbon

Here we report the first known integration of CMOS fabricated silicon light-emitting diodes (SiLED) with single photon avalanche diodes (SPAD) for monolithic optics-free photoluminescence lifetime sensor pixel. We show preliminary results of the photo-exci ...

IEEE2019

Optical-stack optimization for improved SPAD photon detection efficiency

Claudio Bruschini, Rolando Ferrini, Edoardo Charbon, Frédéric Zanella, Marc Schnieper, Scott Anthony Lindner, Ivan Michel Antolovic, Arin Can Ülkü, Ekin Kizilkan

Single-photon avalanche diodes (SPADs) are direct photon-to-digital detectors that enable scalable arrays with Poisson-limited signal-to-noise ratio and picosecond timing resolution. However, SPAD detectors require a guard-ring structure to prevent lateral ...

2019