Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure

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Aims/hypothesistRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA fragments (tRFs) regulating different cellular activities. The aim of this study was to assess the involveme ...

Chimeric antigen receptor (CAR) T-cell therapy continues to struggle in reaching its full potential in solid tumors, largely due to the tumor microenvironment (TME) where various small molecules induce immunosuppressive signaling in CAR T-cells. Two key mo ...

Transcatheter aortic valve implantation (TAVI) is a minimally invasive intervention for the treatment of severe aortic valve stenosis. The main cause of failure is the structural deterioration of the implanted prosthetic leaflets, possibly inducing a valvu ...

In this paper, we present a mathematical model capable of simulating the human cardiac function. We review the basic equations of the model, their coupling, the numerical approach for the computer solution of this mathematical model, and a few examples of ...

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

Hypertrophic Cardiomyopathy (HCM) is a pathological condition characterized by an abnormal thickening of the myocardium. When affecting the medio-basal portion of the septum, it is named Hypertrophic Obstructive Cardiomyopathy (HOCM) because it induces a f ...

Human mammary epithelial cells can proliferate and reorganize into polarized multi-cellular constructs in-vitro, thereby functioning as an important model system in recapitulating key steps of in-vivo morphogenesis. Current approaches to constructing such ...

The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sensing abilities to ...

Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure

Chattez avec Graph Search

tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

Editorial: New marketable discoveries in nanobiotechnology

Boosting CAR T-cell therapy through G-protein signal rewiring

Fluid-structure interaction analysis of transcatheter aortic valve implantation

A mathematical model of the human heart suitable to address clinical problems

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Mammary epithelial morphogenesis in 3D combinatorial microenvironments

The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

Temporal and spatial regularization of persistent atrial fibrillation is associated with arrhythmia free outcome