Publications associées à Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure

Publications associées (10)

tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

Nicolas Jean Philippe Guex, Christian Iseli

Aims/hypothesistRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA fragments (tRFs) regulating different cellular activities. The aim of this study was to assess the involveme ...

SPRINGER2024

Editorial: New marketable discoveries in nanobiotechnology

Sandor Kasas

Lausanne2024

Boosting CAR T-cell therapy through G-protein signal rewiring

Liyan Yang Smeding

Chimeric antigen receptor (CAR) T-cell therapy continues to struggle in reaching its full potential in solid tumors, largely due to the tumor microenvironment (TME) where various small molecules induce immunosuppressive signaling in CAR T-cells. Two key mo ...

EPFL2024

Fluid-structure interaction analysis of transcatheter aortic valve implantation

Alfio Quarteroni

Transcatheter aortic valve implantation (TAVI) is a minimally invasive intervention for the treatment of severe aortic valve stenosis. The main cause of failure is the structural deterioration of the implanted prosthetic leaflets, possibly inducing a valvu ...

Wiley2023

A mathematical model of the human heart suitable to address clinical problems

Alfio Quarteroni

In this paper, we present a mathematical model capable of simulating the human cardiac function. We review the basic equations of the model, their coupling, the numerical approach for the computer solution of this mathematical model, and a few examples of ...

SPRINGER JAPAN KK2023

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Maroun Bou Sleiman, Yang Li, Jean-David Horacio Morel, Giacomo Vincenzo Giorgio Von Alvensleben, Alexis Maximilien Bachmann, Dina Hofer

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Alfio Quarteroni

Hypertrophic Cardiomyopathy (HCM) is a pathological condition characterized by an abnormal thickening of the myocardium. When affecting the medio-basal portion of the septum, it is named Hypertrophic Obstructive Cardiomyopathy (HOCM) because it induces a f ...

FRONTIERS MEDIA SA2022

Mammary epithelial morphogenesis in 3D combinatorial microenvironments

Matthias Lütolf, Mehmet Ugur Girgin

Human mammary epithelial cells can proliferate and reorganize into polarized multi-cellular constructs in-vitro, thereby functioning as an important model system in recapitulating key steps of in-vivo morphogenesis. Current approaches to constructing such ...

NATURE RESEARCH2020

The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

Yimon Aye, Jesse Poganik, Alexandra Krina Van Hall-Beauvais, Yi Zhao

The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sensing abilities to ...

2020

Temporal and spatial regularization of persistent atrial fibrillation is associated with arrhythmia free outcome

Arvind Shah, Laurent Renaud Uldry

2010