Publications associées à An Integrated Transcriptomic Cell Atlas of Human Endoderm-derived Organoids

Publications associées (9)

A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion

Marie Denise Rumpler, Bart Deplancke, Vincent Roland Julien Gardeux, Daniel Alpern, Jörn Pezoldt, Julie Marie Russeil, Guido Van Mierlo, Wouter Jozef L Saelens, Pernille Yde Rainer, Magda Zachara, Radiana Ferrero

Although several mouse and human adipose SVF cellular subpopulations have by now been identified, we still lack an understanding of the cellular and functional variability of adipose stem and progenitor cell (ASPC) populations across human fat depots. To a ...

Cell Press2024

CenFind: a deep-learning pipeline for efficient centriole detection in microscopy datasets

Adrien Julien Félix Journe, Pierre Gönczy, Martin Weigert, Sahand Jamal Rahi, Georgios Hatzopoulos, Léo Arthur Bürgy

BackgroundHigh-throughput and selective detection of organelles in immunofluorescence images is an important but demanding task in cell biology. The centriole organelle is critical for fundamental cellular processes, and its accurate detection is key for a ...

BMC2023

Tissue geometry drives deterministic organoid patterning

Matthias Lütolf, Nathalie Brandenberg, Nikolche Gjorevski, Mikhail Nikolaev, Olga Mitrofanova

Epithelial organoids are stem cell-derived tissues that approximate aspects of real organs, and thus they have potential as powerful tools in basic and translational research. By definition, they self-organize, but the structures formed are often heterogen ...

American Association for the Advancement of Science2022

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have ...

FRONTIERS MEDIA SA2021

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

Matthias Lütolf, Gerardo Turcatti, George Coukos, Nathalie Brandenberg, Krisztian Homicsko, Fabien Kuttler, Nikolche Gjorevski, Camilla Carla Alma Ceroni

Stem-cell-derived epithelial organoids are routinely used for the biological and biomedical modelling of tissues. However, the complexity, lack of standardization and quality control of stem cell culture in solid extracellular matrices hampers the routine ...

NATURE PUBLISHING GROUP2020

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

Etienne Meylan, Caroline Anne-Lyse Contat, Pierre-Benoit Bernard Ancey

Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose usage. The upregulation of GLUTs has been reported in numerous cancer types as a result of perturbation of gene expression or protein relocalization or sta ...

WILEY2018

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko

Commensal microbes colonize the gut epithelia of virtually all animals and provide several benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is associated with numerous pathologies and decreased lifespan. Peptidoglycan ...

2018

Methods & compounds useful in hematopoietic stem cell medicine

Johan Auwerx, Matthias Lütolf, Olaia Maria Naveiras Torres-Quiroga, Mukul Girotra, Nicola Vannini

The present invention relates to a specific marker for stem cells having long-term multi-lineage blood reconstitution capability and uses thereof for the preparation of cell composition in view of hematopoietic stem cell medicine and in particular regenera ...

2016

From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle

Bruno Lemaitre, Elodie Julie Virginie Ramond

Studies on Drosophila hematopoiesis have thus far focused on the embryonic and larval origin of hemocytes, the fly blood cells. In this issue of Developmental Cell, Ghosh et al. (2015) identify adult hematopoietic hubs containing progenitors that can diffe ...

Cell Press - Elsevier2015