Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

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Localized sources of morphogens, called signalling centres, play a fundamental role in coordinating tissue growth and cell fate specification during organogenesis. However, how these signalling centres are established in tissues during embryonic developmen ...

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The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory system. Our mod ...

Background: The impact of acute unilateral injury on spontaneous electrical activity in both vagus nerves at the heart level is poorly understood. We investigated the immediate neuroelectrical response after right or left cardiac vagal nerve transection (V ...

Residual stresses in hot-rolled wide flange steel cross sections may lead to premature yielding, accelerated corrosion and brittle fracture of steel members. The above phenomena lead to a loss of a steel member's stiffness and resistance under mechanical l ...

Dielectric elastomer actuator augmented aorta (DEA) represents a novel approach with high potential for assisting a failing heart. The soft tubular device replaces a section of the aorta and increases its diameter when activated. The hemodynamic interactio ...

Prequalified beam-to-column connections in steel moment resisting frames usually concentrate inelastic deformations in the steel beam ends. As such, nonlinear geo-metric instabilities (i.e., local buckling) may occur in these regions at modest lateral drif ...

BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...

Understanding the influence of running-induced acute fatigue on the homeostasis of the body is essential to mitigate the adverse effects and optimize positive adaptations to training. Fatigue is a multifactorial phenomenon, which influences biomechanical, ...

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

Model-free data-driven computational mechanics (DDCM) is a new paradigm for simulations in solid mechanics. The modeling step associated to the definition of a material constitutive law is circumvented through the introduction of an abstract phase space in ...

IntroductionArterial wave reflection is an important component of the left ventricular afterload, affecting both pressure and flow to the aorta. The aim of the present study was to evaluate the impact of wave reflection on transvalvular pressure gradients ...

A Finite Element Model is developed to represent the mechanical behavior of WC-10 wt.% Co in compression tests. In this research, realistic three-dimensional model is obtained by slicing a sample by Focused Ion Beam and reconstituting it, resulting in two ...

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

In infinite dimensions, many-body systems of pairwise interacting particles provide exact analytical benchmarks for the features of amorphous materials, such as the stress--strain curve of glasses under quasistatic shear. Here, instead of global shear, we ...

Laser powder-bed fusion (LPBF) is an additive manufacturing (AM) process that uses a laser to selectively melt a powder bed. This process can build dense samples with complicated geometries from a wide variety of metallic alloys. In this thesis, LPBF of al ...

Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this en ...

We leverage the crucial hyperelastic properties of a multifunctional structured surface to optimize the reconfigurability of the electromagnetic transmission under large nonlinear mechanical deformations. This multiphysics, multifunctional, hyperelastic st ...

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

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