Mitochondria! function is impaired in the skeletal muscle of pre-frail elderly

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The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied at a brain-wide scale. Here we examined the association bet ...

Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...

A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating ion homeostasis, ...

As the world’s population grows in cities, urban dwellers spend a large amount of time inside their home, making housing health ever more important. Critical for residents’ health, the interactions between indoor residential environments and outdoor enviro ...

Regulation of mitochondrial redox balance is emerging as a key event for cell signaling in both physiological and pathological conditions. However, the link between the mitochondrial redox state and the modulation of these conditions remains poorly defined ...

Animal locomotion is the result of complex and multi-layered interactions between the nervous system, the musculo-skeletal system and the environment. Decoding the underlying mechanisms requires an integrative approach. Comparative experimental biology has ...

Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may interfere with ...

In high-income countries, migration redistributed populations from congested city centres into the sparsely populated outskirts, raising challenges to environmental and population health and the conservation of biodiversity. We evaluate whether this periur ...

The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells ...

Facial paralysis is a highly burdening condition, resulting in a patient's inability to move his mimic musculature on one or both sides of his face. This condition compromises the patient's communication and facial expressions, and thus dramatically reduce ...

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...

Mitochondria! function is impaired in the skeletal muscle of pre-frail elderly

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Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury

Powering the social brain: Mitochondria in social behaviour

Housing, street and health: a new systemic research framework

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population

The end of urban sprawl? Internal migration across the rural-urban continuum in Switzerland, 1966-2018

Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

Real-time actuation of a dielectric elastomer actuator neuroprosthesis for facial paralysis

Impact of population size on early adaptation in rugged fitness landscapes