Publications associées à Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Publications associées (10)

Hyperthermic Intrathoracic Chemotherapy Modulates the Immune Microenvironment of Pleural Mesothelioma and Improves the Impact of Dual Immune Checkpoint Inhibition

Paul Joseph Dyson, Aspasia Gkasti, Yameng Hao

Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural mesothelioma management has improved with the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor c ...

AMER ASSOC CANCER RESEARCH2025

Dissecting the mechanisms of centriole stability in Caenorhabditis elegans: Focus on SAS-1

Keshav Jha

Centrioles are evolutionarily conserved microtubule-based organelles essential for cell division, ciliogenesis, and cell polarity. While centrioles are critical for many cellular processes, their selective elimination is crucial during specific development ...

EPFL2025

Japanese encephalitis virus-associated human microglia induce cell death of human microvascular endothelial cells in receptor-independent infection

Léa Ivana Esméralda Schlunke

Introduction: The neurotropic virus Japanese encephalitis virus invades the human central nervous system, inducing neuroinflammation and further disruption of the blood-brain barrier. JEV interacts with various cell types of the blood-brain barrier includi ...

Frontiers Media SA2025

Deciphering the role of signalling centers in limb development and regeneration

Jixing Zhong

Signaling centers are specialized groups of cells that release morphogens, guiding the fate and behavior of adjacent cells during morphogenesis. For instance, the apical-ectodermal-ridge (AER) in developing limbs, is crucial for coordinating cell fate and ...

EPFL2024

The role of phages for microdiverse bacterial communities in proglacial stream biofilms

Tom Ian Battin, Hannes Markus Peter, Grégoire Marie Octave Edouard Michoud

Viruses modulate the diversity and activity of microbial communities. However, little is known about their role for the structure of stream bacterial biofilm communities. Here, we present insights into the diversity and composition of viral communities in ...

2023

An anti-influenza combined therapy assessed by single cell RNA-sequencing

Francesco Stellacci

Influenza makes millions of people ill every year, placing a large burden on the healthcare system and the economy. To develop a treatment against influenza, we combined virucidal sialylated cyclodextrins with interferon lambda and demonstrated, in human a ...

NATURE PORTFOLIO2022

Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

Alfio Quarteroni

We developed a novel patient-specific computational model for the numerical simulation of ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model reproduces the activity both in sinus rhythm (SR) and in ventricular tachycard ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths

Jacques Fellay

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals wi ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

Matteo Dal Peraro, Bart Deplancke, Vincent Roland Julien Gardeux, Julie Marie Russeil, Alessio Prunotto, Maria Litovchenko, Michael Vincent Frochaux, Antonio Carlos Alves Meireles Filho, Brian Dennis Hollis, Roel Paulus Josephus Bevers, Virginie Sandra Braman

Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transc ...

2021

Electronic Blood Vessel

Shiyu Cheng

Advances in bioelectronics have great potential to address unsolved biomedical problems in the cardiovascular system. By using poly (L-lactide-co-epsilon-caprolactone), which encapsulates liquid metal to make flexible and biodegradable electrical circuitry ...

ELSEVIER2020