Publications associées à Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos

Publications associées (9)

Antagonistic response regulators spatially regulate receptor methylation in the Pseudomonas aeruginosa Pil-Chp surface sensing system

Alexandre Louis André Persat, Marco Julian Kühn

Most bacterial chemosensory systems encode enzymes that are predicted to methylate and demethylate their chemoreceptors to control signaling activity. Here, we show that a predicted methyltransferase (PilK) and methylesterase (ChpB) methylate and demethyla ...

2025

Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence

Agnieszka Alicja Chryplewicz

Glioblastoma recurrence is currently inevitable despite extensive standard-of-care treatment. In preclinical studies, an alternative strategy of targeting tumor-associated macrophages and microglia through CSF-1R inhibition was previously found to regress ...

CELL PRESS2024

Modeling the mechanosensitive collective migration of cells on the surface and the interior of morphing soft tissues

Mahmut Selman Sakar, Jaemin Kim

Cellular contractility, migration, and extracellular matrix (ECM) mechanics are critical for a wide range of biological processes including embryonic development, wound healing, tissue morphogenesis, and regeneration. Even though the distinct response of c ...

Springer Science and Business Media LLC2024

Editorial: Regional and molecular fingerprint of adipogenesis in aging and disease

Josefine Catharina Pedersen Tratwal

FRONTIERS MEDIA SA2023

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

Giovanna Ambrosini

For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the potential neurotoxicity of chemicals before their release in the market, needs to be replaced by new approach methodologies. To illustrate the use of new approach ...

FRONTIERS MEDIA SA2023

Measuring reporter activity domain in EPI aggregates and Gastruloids.ijm

Matthias Lütolf, Olivier Burri, Romain Guiet, Mehmet Ugur Girgin

This imagej macro analyses the reporter intensity activity and expression domain in EPI aggregates and Gastruloids. ...

Zenodo2022

A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation

Freddy Radtke, Bart Deplancke, Ute Koch, Vincent Roland Julien Gardeux, Riccardo Dainese, Daniel Alpern, Jörn Pezoldt, Julie Marie Russeil, Maria Litovchenko, Gerard Llimos Aubach, Judith Franziska Kribelbauer

Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a conceptual framework of h ...

Nature Portfolio2022

Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses

Inès Mariam Castarède

Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ phy ...

2021

Combination of neonatal porcine islets with mesenchymal stem cells of human and porcine origin improves islet function

Sandrine Gerber, Luca Szabó

WILEY2019