Publication

A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle

Publications associées (25)

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

EPFL2022

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells

Sulagna Mukherjee

Recently, adaptive non-shivering thermogenesis has attracted considerable attention because it can elevate energy expenditure and help treat obesity. Despite the numerous reports related to UCP1-driven thermogenesis, little is known regarding UCP1-independ ...

KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING2022

Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

Vera Monica Lemos Da Silva, Eduardo Rochete Ropelle, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. Bioinfo ...

2022

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Johan Auwerx, Maroun Bou Sleiman, Peiling Luan, Davide D'Amico, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Sébastien Robert Victor Herzig, Tanes Imamura de Lima, Qi Wang, Barbara Moreira Crisol

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

2022

Products and methods for promoting myogenesis

Johan Auwerx, Martin Rainer Wohlwend

The present invention relates generally to the field of long non-coding RNAs and transcription factors and modulation of their expression for use in medicine and agriculture, such as the treatment and prevention of diseases associated with muscle atrophy a ...

2022