Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

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Micro-nanotechnology based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recordings of excitable cells. However, electrode geometries alone have failed to produce a cell-electrode interface that is sufficiently ...

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

In graph coarsening, one aims to produce a coarse graph of reduced size while preserving important graph properties. However, as there is no consensus on which specific graph properties should be preserved by coarse graphs, measuring the differences betwee ...

Atomic force microscopy based approaches have led to remarkable advances in the field of mechanobiology. However, linking the mechanical cues to biological responses requires complementary techniques capable of recording these physiological characteristics ...

Volcano-shaped microelectrodes (nanovolcanoes) functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access. These nanovolcanoes exhibit ...

The emerging field of graph signal processing (GSP) allows one to transpose classical signal processing operations (e.g., filtering) to signals on graphs. The GSP framework is generally built upon the graph Laplacian, which plays a crucial role in studying ...

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential, that is the polarization/depola ...

Queries to detect isomorphic subgraphs are important in graph-based data management. While the problem of subgraph isomorphism search has received considerable attention for the static setting of a single query, or a batch thereof, existing approaches do n ...

Brain mechanisms of visual selective attention involve both local and network-level activity changes at specific oscillatory rhythms, but their interplay remains poorly explored. Here, we investigate anticipatory and reactive effects of feature-based atten ...

The distribution of electrolytes in an electric field usually relies on theories based on the Poisson-Boltzmann formalism. These models predict that, in the case of a metallic electrode, ionic charges screen the electrode potential, leading to concentratio ...

Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

Chattez avec Graph Search

Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Graph Coarsening with Preserved Spectral Properties

Volcano-Shaped Scanning Probe Microscopy Probe for Combined Force-Electrogram Recordings from Excitable Cells

Nanovolcano microelectrode arrays: toward long-term on-demand registration of transmembrane action potentials by controlled electroporation

Community-Aware Graph Signal Processing: Modularity Defines New Ways of Processing Graph Signals

Deep learning-based reduced order models in cardiac electrophysiology

Fast and Accurate Efficient Streaming Subgraph Isomorphism

Nested oscillations and brain connectivity during sequential stages of feature-based attention

How to polarise an interface with ions: the discrete Helmholtz model