Publication

Morphological study of early-stage lung cancer using synchrotron radiation

Publications associées (32)

Krab-containing zinc finger protein and cancer

The present invention provides methods for detecting cancer as well as agents and compositions for treating cancer by modulating the expression and/or activity of one or more i) KRAB-containing zinc finger protein (KZFP), ii) mRNA encoding a KZFP, and/or i ...

2022

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

Katarina Pinjusic

Activin-A, a transforming growth factor ê µ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...

EPFL2022

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

Kewen Lei

Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

EPFL2022

Smartphone-Based Visual Inspection with Acetic Acid: An Innovative Tool to Improve Cervical Cancer Screening in Low-Resource Setting

Roser Vinals Terres

Visual inspection with acetic acid (VIA) is recommended by theWorld Health Organization for primary cervical cancer screening or triage of human papillomavirus-positive women living in low-resource settings. Nonetheless, traditional VIA with the naked-eye ...

MDPI2022

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

Nadine Fournier, Douglas Hanahan, Krisztian Homicsko, Mohammad Sadegh Saghafinia, Dalya Ataca, Qiqun Zeng, Mélanie Louise Tichet, Yuqing Xie, Agnieszka Alicja Chryplewicz, Fleuriane Marie Tryskele Laurene Gallean, Jeremy Gilles Louis Guillot, Simge Yücel, Lucine Christe, Peng Zhang, Inti Zlobec

Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

American Association for the Advancement of Science2022

Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients

Didier Trono, Céline Pellaton, Madeleine Suffiotti

IMPORTANCE There are limited comparative data on the durability of neutralizing antibody (nAb) responses elicited by messenger RNA (mRNA) vaccines against the SARS-CoV-2 variants of concern (VOCs) in immunocompromised patients and healthy controls. ...

AMER MEDICAL ASSOC2022

Vlasov description of the beam response to noise in the presence of wakefields in high-energy synchrotrons: beam transfer function, diffusion, and loss of Landau damping

Xavier Buffat, Sondre Vik Furuseth

Noise can have severe impacts on particle beams in high-energy synchrotrons. In particular, it has recently been discovered that noise combined with wakefields can cause a diffusion that leads to a loss of Landau damping after a latency. Such instabilities ...

SPRINGER HEIDELBERG2022

Observational signatures of galactic turbulent dynamos

Jennifer Waltraud Schober, Abhijit Bhausaheb Bendre

We analyse the observational signatures of galactic magnetic fields that are self-consistently generated in magnetohydrodynamic simulations of the interstellar medium through turbulence driven by supernova (SN) explosions and differential rotation. In part ...

OXFORD UNIV PRESS2022

Spectroscopy and dynamics at liquid water interfaces

Bruno Credidio

This thesis is a detailed description of three experimental investigations on aqueous interfaces. All projects made use of the microjet technology or the more recently developed flat-jet technique which enables the implementation of liquid water in vacuum ...

EPFL2022

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

Fabien Louis Claude Robert Jammes

Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...

EPFL2021

Synchrotron Radiation and Sensors: A History of Synergies

Giorgio Margaritondo

Synchrotron radiation has emerged over more than one-half century as a gigantic worldwide enterprise involving tens of thousands of researchers. Its history has been continuously and strongly linked to the technical progress of sensors. We review here diff ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Tomographic reconstruction of the runaway distribution function in TCV using multispectral synchrotron images

Basil Duval, Joan Decker, Umar Sheikh, Gergely Papp, Artur Perek

Synchrotron radiation observed in a quiescent Tokamak a Configuration Variable (TCV) runaway discharge is studied using filtered camera images targeting three distinct wavelength intervals. Through the tomographic simultaneous algebraic reconstruction tech ...

IOP Publishing Ltd2021