Publications associées à Mitochondrial control of ciliary gene expression and structure in striatal neurons

Publications associées (10)

Effects of Tetrahydroindenoindole Supplementation on Metabolism: a Systematic Review with Meta-analysis of Rodent-based Studies

Identifying novel compounds with therapeutic potential is a main area of interest in biomedical research. Tetrahydroindenoindole (THII) has emerged as a compound of interest due to both its antioxidant properties and its action as a pharmacological activat ...

SPRINGER2025

Primary data for "A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network"

Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir

The Septation Initiation Network (SIN) is a conserved signal transduction network, which is important for cytokinesis in S. pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) during anaphase and ...

EPFL Infoscience2024

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

Henning Paul-Julius Stahlberg, Amanda Jennifer Lewis

The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is poorly understood. Standard patient-derived iPSC models develop inclusions neither reproducibly nor in a reasonable time frame. Here, we developed screenable iPSC “in ...

2024

Exploration and modulation of mechanical cues for enhanced cancer immunotherapy

Armand Kurum

The advent of immunotherapy, such as immune checkpoint blockade (ICB) and adoptive transfer of cytotoxic lymphocytes, has transformed the clinical care of cancer. However, a significant proportion of patients are resistant to immunotherapy or experience re ...

EPFL2024

Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

Carlos Canto Alvarez, Jérome Feige, Lucie Camille Chanvillard

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD(+)) levels are hallmarks of skeletal muscle ageing and sarcopenia(1,2,3), but it is unclear whether these defects result from local changes or can be mediated by systemic or dietary c ...

2024

Translating p53-based therapies for cancer into the clinic

Xiaolei Zhou

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all, human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms: mutation of the gene leading to an absence of tumour suppressor activity and, in ...

Nature Portfolio2024

Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3

Matteo Dal Peraro, Daniel Constam, Benjamin Marcel Daniel Rothé, Simon Fortier, Zhidian Zhang

Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRISPR-en ...

PUBLIC LIBRARY SCIENCE2023

Engram cell connectivity as a mechanism for information encoding and memory function

Maurizio Ferdinando Pezzoli

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

Cell Press2023

Lifestyle-coupled evolution of mitosis in close animal relatives

Omaya Pierre Dudin, Marine Olivetta

AMER SOC CELL BIOLOGY2023

Exercise and gait/movement analyses in treatment and diagnosis of Parkinson's Disease

Eduardo Martin Moraud

Cardinal motor symptoms in Parkinson's disease (PD) include bradykinesia, rest tremor and/or rigidity. This symptomatology can additionally encompass abnormal gait, balance and postural patterns at advanced stages of the disease. Besides pharmacological an ...

2023