Time Scales of Slow Motions in Ubiquitin Explored by Heteronuclear Double Resonance

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Dynamic nuclear polarization (DNP) combined with high magnetic fields and fast magic angle spinning (MAS) has opened up a new avenue for the application of exceptionally sensitive 1H NMR detection schemes to study protonated solids. Recently, it has been s ...

129Xe dissolution dynamic nuclear polarization (DNP) is a controversial topic. The gold standard technique for hyperpolarized xenon magnetic resonance imaging (MRI) is spin exchange optical pumping, which received FDA approval in 2022. Nevertheless, the ve ...

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

Microsecond time-resolved cryo-electron microscopy has emerged as a novel approach for directly observing protein dynamics. By providing microsecond temporal and near-atomic spatial resolution, it has the potential to elucidate a wide range of dynamics tha ...

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Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...

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Two methods of post-synthetic modification (Suzuki coupling and CuAAC click-reaction) were applied to Ir(iii) complexes Ir((CN)-N-)(2)(NN)-N- to provide the second highly selective donor site. One family of functionalized complexes was used to d ...

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Structure determination of materials is key to understanding their physical properties. While single-crystal X-ray diffraction is the gold standard for structures displaying long-range order, many materials of interest are polycrystalline and/or disordered ...

The intrinsic low sensitivity of nuclear magnetic resonance (NMR) experiments limits their utility for structure determination of materials. Dynamic nuclear polarization (DNP) under magic angle spinning (MAS) has shown tremendous potential to overcome this ...

We present an alternative to conventional Electron the use of bulky magnets and magnetron equipment, we use the photoluminescence of an ensemble of Nitrogen-Vacancy centers at the surface of a diamond. Monitoring their relaxation time (or T1), we detected ...

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The sensitivity of NMR spectroscopy is considerably enhanced by dynamic nuclear polarization (DNP). In DNP polarization is transferred from unpaired electrons of a polarizing agent to nearby proton spins. In solids, this transfer is followed by the transpo ...

The resolution of proton solid-state NMR spectra is usually limited by broadening arising from dipolar interactions between spins. Magic-angle spinning alleviates this broadening by inducing coherent averaging. However, even the highest spinning rates expe ...

Time Scales of Slow Motions in Ubiquitin Explored by Heteronuclear Double Resonance

Chattez avec Graph Search

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Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Optimal sensitivity for 1H detected relayed DNP of organic solids at fast MAS

129Xe Dynamic Nuclear Polarization Demystified: The Influence of the Glassing Matrix on the Radical Properties

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Microsecond time-resolved cryo-electron microscopy

Microsecond Time-Resolved Cryo-Electron Microscopy

A chemical biology approach to decipher chromatin ubiquitylation by RNF168

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Mechanisms and functions of protein S-acylation

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

Organometallic Ir(iii) complexes: post-synthetic modification, photophysical properties and binuclear complex construction

Hierarchy of the Components in Spray-Dried, Protein-Excipient Particles Using DNP-Enhanced NMR Spectroscopy

NMR Crystallography in the Big Data Era: New Methods and Applications Powered by Machine Learning

Dynamic Nuclear Polarization of Inorganic Halide Perovskites

Fast, Broad-Band Magnetic Resonance Spectroscopy with Diamond Widefield Relaxometry

De novo designed proteins: a study in engineering novel folds and functions

Deuterated TEKPol Biradicals and the Spin-Diffusion Barrier in MAS DNP

Pure Isotropic Proton NMR Spectra in Solids using Deep Learning