3D Architecture and Replaceable Layers for Label-Free DNA Biochips

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Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Florence Gauye, Florian Baier

Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Learning Sparse Graphons And The Generalized Kesten-Stigum Threshold

Emmanuel Abbé

The problem of learning graphons has attracted considerable attention across several scientific communities, with significant progress over the re-cent years in sparser regimes. Yet, the current techniques still require diverg-ing degrees in order to succe ...

INST MATHEMATICAL STATISTICS-IMS2023

Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms

Corinne Scaletta, Lee Ann Laurent-Applegate, Philippe Abdel Sayed, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay

Cryopreservation and lyophilization processes are widely used for conservation purposes in the pharmaceutical, biotechnological, and food industries or in medical transplantation. Such processes deal with extremely low temperatures (e.g., -196 degrees C) a ...

MDPI2023

Photonic radar for contactless vital sign detection

Yang Liu

Vital sign detection is used across ubiquitous scenarios in medical and health settings, and contact and wearable sensors have been widely deployed. However, they are unsuitable for patients with burn wounds or infants with insufficient areas for attachmen ...

Nature Publishing Group2023

A data fusion approach for ride-sourcing demand estimation: A discrete choice model with sampling and endogeneity corrections

Michel Bierlaire

Ride-sourcing services offered by companies like Uber and Didi have grown rapidly in the last decade. Understanding the demand for these services is essential for planning and managing modern transportation systems. Existing studies develop statistical mod ...

2023

Optimizing Sales Forecasting, Inventory, Pricing and Sourcing Decisions

Yara Kayyali El Alem

In this thesis we address various factors that contribute both theoretically and practically to mitigating supply demand mismatches. The thesis is composed of three chapters, where each chapter is an independent scientific paper. In the first paper, we dev ...

EPFL2023

Electronic readout of DNA amplification in nanoliter chambers. Strategies towards highly parallel semiconductor-based nucleic acid amplification testing

Saurabh Tomar

Polymerase chain reaction (PCR) has been the most significant driver in the field of nucleic acid testing (NAT) since its invention. Popularized as an abbreviation by the Covid-19 pandemic, PCR-based methods are the gold standard in the field of diagnostic ...

EPFL2023

ISP: Multi-Layered Garment Draping with Implicit Sewing Patterns

Pascal Fua, Benoît Alain René Guillard, Ren Li

Many approaches to draping individual garments on human body models are realistic, fast, and yield outputs that are differentiable with respect to the body shape on which they are draped. However, they are either unable to handle multi-layered clothing, wh ...

2023

Fast correlation function calculator A high-performance pair-counting toolkit

Cheng Zhao

Context. A novel high-performance exact pair-counting toolkit called fast correlation function calculator (FCFC) is presented.Aims. With the rapid growth of modern cosmological datasets, the evaluation of correlation functions with observational and simula ...

EDP SCIENCES S A2023

Fast Parallel Algorithms for Enumeration of Simple, Temporal, and Hop-Constrained Cycles

Paolo Ienne, Kubilay Atasu, Jovan Blanusa

Finding cycles in directed graphs enables important applications in various domains such as finance, biology, chemistry, and network science. However, as the size of graph datasets continues to grow, it becomes increasingly difficult to discover cycles wit ...

arXiv2023

Automated image-based generation of finite element models for masonry buildings

Katrin Beyer, Radhakrishna Achanta, Bryan German Pantoja Rosero

To predict the response of masonry buildings to various types of loads, engineers use finite element models, specifically solid-element and macro-element models. For predicting masonry responses to seismic events in particular, equivalent frame models-a su ...

SPRINGER2023

Human PBMCs Form Lipid Droplets in Response to Spike Proteins

Florian Maria Wurm

Intracellular lipid droplets (LDs) can accumulate in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood mononuclear ...

MDPI2023