Publication

Mycobacterium lepromatosis Infections in Nuevo Leon, Mexico

Publications associées (27)

Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence

Stewart Cole, Anna De Graff Tischler, Neeraj Dhar, Florence Pojer, Jeffrey Chen, Ming Zhang, Jan Lars Rybniker

The EspA protein of Mycobacterium tuberculosis is essential for the type VII ESX-1 protein secretion apparatus, which delivers the principal virulence factors ESAT-6 and CFP-10. In this study, site-directed mutagenesis of EspA was performed to elucidate it ...

American Society for Microbiology2013

2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections

Stewart Cole

The present invention relates to new 2-piperazin-1-yl-4H-1,3-benzothiazin- 4-one derivatives and their use for the treatment of mammalian infections caused by bacteria, especially diseases like tuberculosis (TB), Buruli ulcer and leprosy that result from i ...

2012

A Case of Diffuse Lepromatous Leprosy associated with Mycobacterium lepromatosis

Stewart Cole, Philippe Busso, Pushpendra Singh

An 86-year old female patient from northeast Mexico presented with diffuse lepromatous leprosy (DLL). Sequence analysis of four genes (rrs, rpoB, sigA and hsp65) from the skin biopsy identified Mycobacterium lepromatosis. This is the first independent conf ...

2011

Probable zoonotic leprosy in the southern United States

Stewart Cole, Adamantia Kapopoulou, Jacques Rougemont, Philippe Busso, Pushpendra Singh, Rahul Sharma

In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure. In the same region, as well as in Mexico, wild armadillos are infected wi ...

2011

Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America

Stewart Cole, Philippe Busso, Pushpendra Singh

Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two ...

2011

Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

Stewart Cole

We have amplified Mycobacterium leprae DNA from the skeleton of an adult human female exhibiting signs of lepromatous leprosy (LL). The remains were excavated from the site of Devkesken 6 on the Ustyurt plateau of Uzbekistan and date to between the 1st and ...

2009

Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?

Stewart Cole

Comparative genomics analysis of the Tamil Nadu strain of Mycobacterium leprae has uncovered several polymorphic sites with potential as epidemiological tools. In this study we compared the stability of two different markers of genomic biodiversity of M. l ...

2008