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Alzheimer's drug turns macrophages against cancer

Michele De Palma, Amaia Martinez Usatorre
2021
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Michele De Palma, Amaia Martinez Usatorre
2021
Journal Articles

Source officielle

Publications associées (12)

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https://infoscience.epfl.ch/entities/publication/9dc17e4d-818e-4cf9-b9e4-efcda286e7e4

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Publications associées (12)

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The past decade has witnessed a revolution in cancer treatment, shifting from conventional drugs (chemotherapies) towards targeted molecular therapies and immune-based therapies, in particular immune-checkpoint inhibitors (ICIs). These immunotherapies rele ...

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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

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Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug discovery. So fa ...

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Identifying resistance mechanisms and combination therapies in Notch-driven triple negative breast cancer

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Triple negative breast cancer (TNBC) is known to be the most aggressive type of breast cancer (BC) and is primarily treated with chemotherapy. Nonetheless, new therapeutic options are urgently needed. Advances in next-generation sequencing have identified ...

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