Publications associées à Hypoxia Impairs Skin Myofibroblast Differentiation and Function

Publications associées (31)

First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting

In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(epsilon-caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution ele ...

Wiley-V C H Verlag Gmbh2024

Polysaccharide Breakdown Products Drive Degradation-dispersal Cycles of Foraging Bacteria Through Changes in Metabolism and Motility

Martin Ackermann

Most of Earth's biomass is composed of polysaccharides. During biomass decomposition, polysaccharides are degraded by heterotrophic bacteria as a nutrient and energy source and are thereby partly remineralized into CO2. As polysaccharides are heterogeneous ...

eLIFE SCIENCES PUBL LTD2024

How to Make Elastomers Piezoelectric?

Frank Nüesch, Francis Owusu

Piezoelectrics play a significant role in modern electronics and electric devices. Thermal or mechanical stress on such materials induces a change in polarization generating an electric response, which is the sole effect of why they are so interesting. How ...

Wiley2023

Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation

Dominique Pioletti, François Gorostidi, Yanheng Guo, Theofanis Stampoultzis, Vijay Kumar Rana, Ece Mailand

Tissue wounds are a significant challenge for the healthcare system, affecting millions globally. Current methods like suturing and stapling have limitations as they inadequately cover the wound, fail to prevent fluid leakage, and increase the risk of infe ...

Amer Chemical Soc2023

Fast Self-Assembly Dynamics of a beta-Sheet Peptide Soft Material

Sandor Kasas

Peptide-based hydrogels are promising biocompatible materials for wound healing, drug delivery, and tissue engineering applications. The physical properties of these nanostructured materials depend strongly on the morphology of the gel network. However, th ...

WILEY-V C H VERLAG GMBH2023

Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications

Pierre-Arnaud Aeberhard, Dominique Pioletti, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Jens Antons, Anthony Grognuz

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...

2020

Advances in the Sensing and Treatment of Wound Biofilms

Hubert Girault, Sorour Darvishi

Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of th ...

Wiley-VCH Verlag GmbH2022

A Homogenization Model for Soft Magnetic Composites Considering the Effect of Mechanical Stress

Xiaotao Ren

Soft Magnetic Composites (SMC) are an alternative to laminated steels for the design of smaller and lighter electromagnetic devices.Such electromagnetic devices might be subjected to significant mechanical stresses that can alter their electromagnetic prop ...

Institute of Electrical and Electronics Engineers2022

Volume change characteristics of fine-grained soils due to sequential thermo-mechanical stresses

Alessio Ferrari

Know-how of volume change characteristics, VCC, of the fine-grained soils, exposed to thermal stresses, is essential for design of various thermo-active structures. These stresses are known to induce excess pore-water pressure, Δu θ , in the saturated stat ...

2019

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

Promising eco-friendly biomaterials for future biomedicine: Cleaner production and applications of Nanocellulose

Edgard Gnansounou

Cellulose nanomaterials are developing nowadays as a promising environmental friendlier biomaterial that can be extracted from native plant sources. These materials, because of their excellent physico-chemical and biological properties, urged much interest ...

ELSEVIER2021

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Luca Barbarotta, Alfio Quarteroni, Luca Dede', Simone Rossi

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

Laura Capolupo

Cell-to-cell variability plays a key role in tissue patterning by setting initial asymmetry that primes cell fate decisions. Fluctuations in the activity of regulatory molecules can commit individual cells to divergent differentiation pathways, and cell-to ...

EPFL2021

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

Johan Auwerx, Elena Katsyuba, Hongbo Zhang

Protein lysine acetylation is a post-translational modification that regulates protein structure and function. It is targeted to proteins by lysine acetyltransferases (KATs) or removed by lysine deacetylases. This work identifies a role for the KAT enzyme ...

Rockefeller University Press2021

Podosomes, But not the Maturation status, Determine the Protease-Dependent 3D Migration in human Dendritic cells

Romain Guiet

Dendritic cells (DC) are professional Antigen-Presenting Cells scattered throughout antigen-exposed tissues and draining lymph nodes, and survey the body for pathogens. Their ability to migrate through tissues, a 3D environment, is essential for an effecti ...

2018

Progress in Self-Healing Fiber-Reinforced Polymer Composites

Véronique Michaud, Amaël Maximilien Cohades

This paper sets out to review the current state of the art in applying self-healing/self-repair to high-performing advanced fiber-reinforced polymer composite materials (FRPs). A significant proportion of self-healing studies have focused so far on develop ...

WILEY2018

On cavitation inception and cavitating flow patterns in a multi-orifice microfluidic device with a functional surface

Luis Guillermo Villanueva Torrijo

During the last decade, hydrodynamic cavitation has been implemented in various applications such as energy harvesting and biomedical applications. Facile hydrodynamic cavitation methods are required for fulfilling the requirements in these applications. I ...

AMER INST PHYSICS2021

Microstructured Biodegradable Fibers for Advanced Control Delivery

Fabien Sorin, Alexis Gérald Page, Dang Tùng Nguyen, Andreas Leber, Inès Richard, Govindan Narayanan Krishnamani, Shahrzad Shadman Yazdi

Biodegradable polymers are increasingly employed at the heart of therapeutic devices. Particularly in the form of thin and elongated fibers, they offer an effective strategy for controlled release in a variety of biomedical configurations such as sutures, ...

WILEY-V C H VERLAG GMBH2020

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Esra Güç, Manuel Andreas Fankhauser

Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...

2017