Publication

Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics

Publications associées (28)

Ordinary varieties with trivial canonical bundle are not uniruled

Zsolt Patakfalvi, Maciej Emilian Zdanowicz

We prove that smooth, projective, K-trivial, weakly ordinary varieties over a perfect field of characteristic p>0 are not geometrically uniruled. We also show a singular version of our theorem, which is sharp in multiple aspects. Our work, together with La ...

2021

Global Frobenius liftability I

Maciej Emilian Zdanowicz

We formulate a conjecture characterizing smooth projective varieties in positive characteristic whose Frobenius morphism can be lifted modulo p(2)-we expect that such varieties, after a finite stale cover, admit a toric fibration over an ordinary abelian v ...

2021

Low-energy electron holography imaging of conformational variability of single-antibody molecules from electrospray ion beam deposition

Klaus Kern, Stephan Rauschenbach, Sabine Abb, Sven Alexander Szilagyi, Hannah Julia Ochner

Imaging of proteins at the single-molecule level can reveal conformational variability, which is essential for the understanding of biomolecules. To this end, a biologically relevant state of the sample must be retained during both sample preparation and i ...

National Academy of Sciences2021

Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation

Corey Alfred Stevens

Carbohydrate recognition by lectins governs critical host-microbe interactions. MpPA14 (Marinomonas primoryensis PA14 domain) lectin is a domain of a 1.5-MDa adhesin responsible for a symbiotic bacterium-diatom interaction in Antarctica. Here, we show that ...

Amer Soc Microbiology2021

Modular Chiral N-Heterocyclic Carbene Ligands for the Nickel-Catalyzed Enantioselective C-H Functionalization of Heterocycles

Nicolai Cramer, Johannes Diesel

N-Heterocyclic carbenes (NHCs) are the ligands of choice in a large variety of transformations entailing different transition metals. However, the number and variety of chiral NHCs suitable as stereo-controlling ligands in asymmetric catalysis remains limi ...

2020

Colloidal Synthesis of Cu-M-S (M = V, Cr, Mn) Nanocrystals by Tuning the Copper Precursor Reactivity

Raffaella Buonsanti, Seyedehbehnaz Varandili, Valeria Mantella, James Richard Pankhurst

New ternary and higher order inorganic materials are needed for a large variety of applications, yet their synthesis still represents a chemistry challenge. Herein, we focus on the synthesis of Cu-M-S nanocrystals (where M = V, Cr, Mn) via a wet-chemistry ...

2020

Unsupervised Representation Learning for Gaze Estimation

Jean-Marc Odobez, Yu Yu

Although automatic gaze estimation is very important to a large variety of application areas, it is difficult to train accurate and robust gaze models, in great part due to the difficulty in collecting large and diverse data (annotating 3D gaze is expensiv ...

IEEE2020

A comprehensive error rate for multiple testing

Stephan Morgenthaler, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville

Over the last two decades, a large variety of type I error rates and control procedures have been proposed in the field of multiple hypotheses testing. This paper proposes a framework that includes many existing proposals by investigating procedures in whi ...

SPRINGER2020