Publications associées à Polysaccharide Breakdown Products Drive Degradation-dispersal Cycles of Foraging Bacteria Through Changes in Metabolism and Motility

Publications associées (13)

Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells

Endoplasmic reticulum (ER) retention of misfolded glycoproteins is mediated by the ER-localized eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognizes a misfolded glycoprotein and flags it ...

Wiley2024

The role of LRRK2 in lung adenocarcinoma

Aspasia Gkasti

Lung cancer is the leading cause of cancer-related deaths worldwide and the most common lung cancer subtype is lung adenocarcinoma (LUAD). Frequently mutated genes involve activating mutations in KRAS and loss of function mutations in TP53. LUADs primarily ...

EPFL2024

Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox responses in larval fish

Yimon Aye, Kuan-Ting Huang, Sruthi Raja

This Protocol Extension describes the adaptation of an existing Protocol detailing the use of targetable reactive electrophiles and oxidants, an on-demand redox targeting toolset in cultured cells. The adaptation described here is for use of reactive elect ...

NATURE PORTFOLIO2023

Protocol for live imaging of intracellular nanoscale structures using atomic force microscopy with nanoneedle probes

Marcos Penedo Garcia

Atomic force microscopy (AFM) is capable of nanoscale imaging but has so far only been used on cell surfaces when applied to a living cell. Here, we describe a step-by-step protocol for nanoendoscopy-AFM, which enables the imaging of nanoscale structures i ...

2023

Development of next-generation microfluidic systems for enhanced, faster, and cost-effective immunoassays for tissue diagnostics - Ac electrothermal flow & Acoustofluidics

Muaz Salama Abdelmonem Draz

The application of microfluidics in the field of surface-based assays and more specifically, the spatial molecular profiling of tumor tissues has gained a lot of interest, especially with the increased interest in personalized medicine and targeted therapy ...

EPFL2023

Glacier-Fed Stream Biofilms Harbor Diverse Resistomes and Biosynthetic Gene Clusters

Tom Ian Battin, Hannes Markus Peter, Tyler Joe Kohler, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Stylianos Fodelianakis, Massimo Bourquin, Leïla Ezzat, Paraskevi Pramateftaki, Matteo Tolosano, Vincent Henri De Staercke, Michail Styllas

Antimicrobial resistance is an omnipresent phenomenon in the anthropogenically influenced ecosystems. However, its role in shaping microbial community dynamics in pristine environments is relatively unknown. ...

AMER SOC MICROBIOLOGY2023

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

Johan Auwerx, Elena Katsyuba, Hongbo Zhang

Protein lysine acetylation is a post-translational modification that regulates protein structure and function. It is targeted to proteins by lysine acetyltransferases (KATs) or removed by lysine deacetylases. This work identifies a role for the KAT enzyme ...

Rockefeller University Press2021

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Denis Duboule, Lucille Delisle

In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2021

Chemistry and Analysis of Nanoparticle-Modified Living Cells

Tanja Thomsen

Conventional therapeutics are often limited by their targeting ability, resulting in harmful and potential fatal side-effects for the patients. Recently, new strategies have been developed to improve target specificity of drugs in order to generate more ef ...

EPFL2020

Multifunctional hybrid alginate-based hydrogels for cell immobilization

Luca Szabó

Cell therapy could be a solution for many diseases that currently pose a huge health burden on patients. Especially, cell therapies based on cell microencapsulation are of great interest. Immunoprotection of cells would allow to avoid the need for immunosu ...

EPFL2020

Cross-linkable polymer, hydrogel, and method of preparation thereof

Dominique Pioletti, Christophe Moser, Pierre-Etienne Bourban, Peyman Karami, Céline Samira Wyss

The invention relates to a cross-linkable polymer comprising a base polymer comprising functional groups at least some of which have been reacted with a first organic molecule comprising a cross-linkable unit and with a second organic molecule capable of b ...

2020

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

Christina Ernst

Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we iden ...

Nature Research2020

Cell-free gene-regulatory network engineering with synthetic transcription factors

Sebastian Maerkl, Zoe Newell Swank, Nadanai Laohakunakorn

Gene-regulatory networks are ubiquitous in nature and critical for bottom-up engineering of synthetic networks. Transcriptional repression is a fundamental function that can be tuned at the level of DNA, protein, and cooperative protein-protein interaction ...

National Academy of Sciences2019